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Looking for specific microbes helps identify cancer; aids in early treatments

10月

14日

image source: dreamstime.com

Subhajyoti De, associate professor of cancer systems biology at Rutgers Cancer Institute of New Jersey together with RWJBarnabas Health, found that microorganisms may be new targets for earlier diagnosis or treatment of pancreatic cancer (1).

According to the October 10 2022 Rutgers University press release, they were able to identify tumor-associated microbes and measure the activity of the host cells at the same time. They examined the microbiome of pancreatic tumors and identified particular microorganisms that are associated with inflammation and poor survival (2).

Short of two weeks earlier, research by Lian Narunsky Haziza, a cancer biologist at the Weizmann Institute of Science in Israel, found that tumors contain millions of microbes and fungi, representing dozens of species, according to a September 29 2022 New York Times article (2).

So-called tumor microbiome is proving so distinctive in each type of cancer that some scientists hope to find early signs of hidden tumors by measuring the microbial DNA they shed into the blood, says the study led by Dr. Haziza.

1) https://www.rutgers.edu/news/microorganisms-tumors-may-help-identify-new-approaches-treating-pancreatic-cancer

2) https://www.nytimes.com/2022/09/29/science/cancer-tumors-fungi-bacteria-microbiome.html

#bacteria #cancercells #guthealth #gutmicrobiome #healthinnovation #microbiome #tumor

Healthy stool from fecal transplant in an IBS patient's digestive track reduces symptoms

9月

30日

source: dreamstime

Stool with healthy microorganisms inserted into a person’s digestive tract has been shown to reduce abdominal stress and tiredness in patients with irritable bowel syndrome (IBS), according to a September 13, 2022 article in Everyday Health.

The efficacy of this inexpensive treatment has shown to last three years for over 90% of patients, and beyond three years for over 70% of patients, according to the report by author Magdy El-Salhy, MD, a gastroenterologist at Stord Helse Fonna Hospital in Norway. Her team found that dysbiosis, a gut micriobiome imbalance, was lower among those receiving active treatment after two to three years.

https://www.everydayhealth.com/ibs/fecal-transplant-provides-relief-from-irritable-bowel-syndrome-symptoms/

#dysbiosis #guthealth #gutmicrobiome #ibs

Adaptive Biotech gets creative with financing

9月

24日

A worthwhile digression from Herbsprout’s standard health topics, Seattle-based biotech Adaptive Biotechnologies Corp. (Nasdaq: ADPT) came up with up to $250 million in innovative/ creative financing during the current economic downturn. The deal mix of business development revenue share with financing.

According to a September 14 2022 Puget Sound Business Journal report, the company inked a royalty financing agreement with health care investment firm OrbiMed. Adaptive is developing an immune system platform to build a data-driven, “clinical-product development engine”. With the immune system as the “source code”, Adaptive says it can develop diagnostics and therapeutics for almost any disease, according to the company.

Through the agreement, Adaptive will receive an initial $125 million in exchange for OrbiMed receiving 5% of Adaptive's revenue. Adaptive can receive an additional $75 million for 8% of its revenue and another $50 million, earmarked for potential merger and acquisition deals, for 10%.

"This was a really nice creative structure because for us, we didn't want to raise equity capital and dilute the shareholder base when our stock is trading significantly below historical levels," said Chad Robins, co-founder and CEO of Adaptive is quoted Puget Sound Business Journal. “Debt will have a balloon payment or an amortization where if for any reason the markets aren't there and you can't recapitalize or you can't repay that debt, that provides a lot of risk to a company."

Adaptive will have to pay OrbiMed back 1.65 times whatever it takes, but the rate decreases if Adaptive can pay the firm back in 18 or 24 months, Robins said. He added that although there is a $50 million tranche reserved for M&A, Adaptive isn't targeting anything specific right now. According to Robins, the company will lay out a path to profitability in its third quarter earnings, and this money will help Adaptive reach that goal without having to raise equity capital.

https://www.bizjournals.com/seattle/inno/stories/fundings/2022/09/14/adaptive-royalty-financing-agreement-orbimed.html

Sleep Apnea underdiagnosed in connection to cardiovascular diseases

9月

18日

source: sleep apnea occurs in 40% of cardiovascular disease patients.

Obstructive sleep apnea (OSA) is one of the most common and serious sleep-related breathing disorders with a strong connection to patients with cardiovascular (CV) diseases.

Despite its prevalence, OSA is often underdiagnosed and untreated, even though it can increase risk of heart failure, arrhythmias, hypertension, and coronary artery disease, according to an August 11 2022 report by Handawi journal. The report claims that sleep apnea occurs in more than 40% of CV patients.

In addition to CV diseases, sleep apnea can result in repetitive upper airway collapse during sleep and insufficient oxygen.

https://www.hindawi.com/journals/cdtp/2022/6006127/

treating depression by supporting our gut microbiome

9月

10日

source: dreamstime

The gut microbiome can be a promising approach for the management of depression. A September 7, 2022 Science Direct report suggest that the gut microbiota control the host epigenetic machinery in depression.

Gut dysbiosis causes negative epigenetic modifications via mechanisms like histone acetylation, DNA methylation and non-coding RNA mediated gene inhibition.

The diet and dietary metabolites like kynurenine, tryptophan, and propionic acid also greatly influence the microbiome composition and the physiological activities.

Science Direct point out that stress is one of the important risk factors for depression that results from chronic or early life stress, in the range of 37% to 48% showing a strong relation between family history and depression.

https://www.sciencedirect.com/science/article/abs/pii/S0166432822003497

“Live Long and Prosper” with ketones & polyphenols

9月

4日

source: dreamstime

Distinguished doctor and medical researcher Dr. Steve Gundry says polyphenols aid in everything from heart health to gut health and weight loss. Why? Based on his research, Dr. Gundry discovered these polyhenols facilitate caloric bypass, enabling the mitochondria in our body to ignore excessive amounts of food, and bypass converting them into stored fats (1).

More than 8,000 polyphenols are out there, and they are divided into four main categories: flavonoids, stilbenes, lignans, and phenolic acids, according to a May 24, 2022 Wellandgood.com article (2).

Ketones created by our liver are even more effective than the polyphenol foods, in fact the most effective at signaling caloric bypass, but helps all your cells work better, according to the National Institute of Aging.

Dr. Gundry discovered medium chain triglycerides (MCT) naturally found in certain foods, can never be converted to fats and can only be converted to ketones. Both Columbia and McGill Universities confirmed studies that individuals who consume increasing amounts ketones showed significant decreases in body fat and weight. He found that communities that consume large amounts of — goat cheese sheeps milk, acacia, and coconut oil — each of which are among the largest sources of MCTs, are also among the longest living communities in the world (1).

Top sources of MCTs are coconut and coconut products - coconut oil, coconut butter and full fat coconut milk; palm kernel oil; and in lesser amounts- butter, milk, yogurt and cheese 3).

Top sources of polyphenols include Herbs and Spices such as ginger and turmeric, Cocoa, and berries such as blackberries, blueberries, and strawberries (2).

1) https://fb.watch/feicm0Zfwq/

2) https://www.wellandgood.com/polyphenols/#main-content

3) https://www.healthline.com/nutrition/mct-oil-101

Gut bacteria that regulates cholesterol

8月

25日

A subset of bacteria called Bacteroides help to regulate cholesterol levels in the blood by producing cholesterol sulfate, according to postdoctoral researchers Henry Le and Ming-Ting Lee at the College of Agriculture and Life Sciences, co-first authors of the study (1).

Though more study is needed, early clues reveal cholesterol sulfate acts as a signaling molecule for a slew of biological pathways, according to a study published August 18 in Nature Microbiology and reported by Phys.org (1).

National Institute of Health says cholesterol sulfate is metabolized in different pathways. While it’s function of remains an enigma, cholesterol sulfate has emerged as a regulatory molecule, and serves an important stabilizing role (2).

1) https://phys.org/news/2022-08-gut-bacteria-cholesterol.amp

2) https://pubmed.ncbi.nlm.nih.gov/12730293/

Microbe found to generate electricity

8月

11日

source: freeimages

A sediment organism Geobacter sulfurreducens, first found along the Potomac River, has been discovered to generate an electrical charge, according to a February 2020 article in BigThink.

The microbe a member of the Geobacter genus, a group known as “electrigens” for their known ability to generate an electrical charge. “It was UMass Amherst microbiologist Derek Lovley who found and wrote about the microbe in the late 80s,” according to Big Think.

He found that the microbe produces electrically conductive protein nanowires, and his lab recently developed a new Geobacter strain that could produce them more rapidly and inexpensively. Lovely worked together with electrical engineer Jun Yao, also of UMass Amherst, to create a device they call “ air-gen”, creating “electricity out of thin air.” The Air-gen generates clean energy 24/7. “It’s the most amazing and exciting application of protein nanowires yet,” he’s quoted saying in BigThink.

https://bigthink.com/the-present/air-gen/

Stool Bank for fecal transplant?

7月

22日

image source: dreamstime.com

Fecal transplants don’t work from one person to another. But what about transplants of your younger self?

Researchers at Harvard Medical School and Brigham and Women’s Hospital claim it’s a good idea for people to bank their stool samples when they’re young and healthy to rejuvenate their gut microbiome, according to a June 30 2022 article in The Scientist (1). Dr. Scott Weiss and Yang-Yu Liu propose this stool bank for fecal transplant(s) for use later in life.

As scientists discover the importance of personalized medicine as the most effective approach to addressing a person’s individually unique health care needs, these researchers and others believe the key to its efficacy lies in a person’s past.

Already, a company in Singapore is thinking along the same lines. Cord life is the first company to work with the Asian Microbiome Library in Singapore to collect “precision” databank of stool samples (2).

1) https://www.the-scientist.com/news-opinion/banking-previous-poos-could-a-transplant-of-feces-from-your-past-heal-you-70180

2) https://thehomeground.asia/destinations/singapore/faecal-attraction-first-southeast-asia-poo-bank-set-up-in-singapore/

Lactobacillus helps reduce depression

7月

1日

A study found that an increase consumption of bacteria called Lactobacillus shows a 15% reduction in showing symptoms of depression. the gut flora of the participants who received the probiotic, according to a study by Dr. Graham Rook, emeritus professor of medical microbiology with the University College London.

https://www.medicalnewstoday.com/articles/probiotics-could-good-gut-bacteria-help-tackle-depression#Study-limitations-and-next-steps

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自己紹介

By HerbSprout.com

https://herbsprout.home.blog/ HERBSPROUT ADVISORY BOARD: ___________________________

●Jenny Pandol, Co-owner/founder/ COO, Microbiome Learning Center;
●Dr. Sabine Hazan, Founder and CEO, Progenabiome and Ventura Clinical Trials;
●Naveen Jain, Founder & CEO, Viome
●Hans Parge, ex-Pfizer director;
●Rob Greenlee, VP, Libsyn;
___________________________

●Cindy Postma, essential oils;
●Chris Kenji Beer, herbs & microbiome;
●Ely Diana, translation/ support services.
___________________________

Cindy Postma has been a writer and editor across all disciplines. She has been an instructor of Asian studies at Kings College (Cambridge), Columbia, and Cornell. She received her PhD from Kyoto University, Masters from Columbia University, and undergraduate from The University of Washington. She is proficient in four Asian languages and French. ____________________________

I am Chris Kenji Beer, Herbsprout writer and editor. I come from a family of health nuts. My mom was a psyche major and shared her Japanese culinary tradition. Uncle Tetsuo was and cousin Satoru Harada is a surgeon. Aunt Shigeko was a dietitian in Hiroshima before complications from the nuclear fallout took her life. I am currently enrolled at Bastyr University's Ayurvedic Health Advisor program. In the past, I spent many years researching health care. I was published on the topic "Japanese Health Care for the Elderly" by the U.S. - Japan Foundation, and as co-author of health care reports for National Conference of State Legislatures Health Services Program, NW Asian Weekly, & as Editor/ co-Publisher of Asia Pacific Economic Review. Email us with questions or comments @ sales@mzinger.com. ____________________________

The contents of this webblog is not intended to be used to treat, cure, mitigate, or diagnose any medical condition. The readers must consult your doctor before you make any changes that could affect your health.