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more studies confirm herbs aid in microbial diversity, gut health

2月

21日

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“Research has shown that people who have a lot of different microbes have better health, and a better diet, than those who don’t have much bacterial diversity,” says Penny M. Kris-Etherton, Evan Pugh University Professor of Nutritional Sciences, Penn State, in a February 7, 2023 SciTech Daily report (1).

According to The Journal of Nutrition, scientists analyzed the impact of adding blends of eating peanuts, herbs and spices — such as cinnamon, ginger, cumin, turmeric, rosemary, oregano, basil, and thyme (2). An increase of snacking on peanuts of 28 grams (approx. 1 ounce) per day showed significant improvement in the abundance of Ruminococcaceae, a gut bacteria associated with butyrate production, healthy immune and liver function. A mid to high (3/4 – 1 1/2 teaspoons per day) consumption of the aforementioned herbs and spices showed significant increases in bacteria diversity, including Ruminococcaceae over a one month test period (2).

 
1) https://www.clinicalnutritionjournal.com/article/S0261-5614(22)00290-4/fulltext

2) https://scitechdaily.com/just-a-teaspoon-adding-herbs-and-spices-to-your-diet-could-improve-gut-health/

https://herbsprout.home.blog/2023/01/13/good-foods-herbs-for-our-gut/

2x Weekly New Posts have moved to Herbsprout.com

2月

11日

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This Herbsprout blog has moved to the following live linked:

HTTP://HERBSPROUT.COM.


Visit this site for weekly updates on the Herbsprout gut Microbiome health blog. Thank you for your interest.

Wormwood – more on herbs that support a healthy gut

1月

23日

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To maintain a healthy gut, it begins with the food you eat. With proper health professional support, herbs can be valuable supplements to your daily food diet and medicinal remedies.
While Herbsprout is not in the business of endorsing herbal supplements, Primal Herb’s website provides valuable information/ research about herbs they use in their product which support a healthy gut.

For example, studies confirm that wormwood contains antimicrobial and antifungal properties that keep dangerous bacteria and fungi at bay, such as the well known e. coli and salmonella. Other gut related disorders that could benefit from wormwood are SIBO (or small intestinal bacteria overgrowth), Candida, and Crohn’s disease.

One reason for its efficacy, wormwood contains a powerful ingredient called artemisinin. Studies by Mateon Therapeutics confirmed that artemisinin effectively inhibits COVIC-19 from multiplying, while also having a high safety index. In addition to wormwood, artemisinin is a natural derivative from the Asian herb Artemisia.

https://primalherb.com/natural-ways-to-restore-gut-health-and-digestion

https://www.biospace.com/article/releases/mateon-expands-its-covid-19-therapeutic-program-to-include-artemisinin

healthy butyrate can be produced from almonds

10月

30日

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A clinical study led by Kings College London Professor of Dietetics Kevin Whelan investigated how gut microbes break down almonds to produce butyrate, a specific microbiota product associated with several health benefits.

This new research found that consuming almonds significantly increases butyrate, a type of beneficial short-chain fatty acid (SCFA) produced by microbes in the colon when they digest fiber. Butyrate is the primary fuel source for colonocytes, the cells that line the colon, according to the study funded by the Almond Board of California. 87 healthy adults participated in this 4-week study.

Results from the study showed significant differences in stool frequency as well as significant increases in butyrate in the colon. Other measured outcomes from the study included relative abundance of fecal bifidobacteria, fecal microbiota composition and diversity, fecal SCFAs, whole-gut transit time, gut pH, stool output (both frequency and consistency), and gut symptoms.

https://www.prnewswire.com/news-releases/almond-consumption-may-benefit-some-gut-microbiota-functionality-study-finds-301651443.html?tc=eml_cleartime

For further information on the study, contact Megan Brodsky, #206-697-9212, or Megan.brodsky@porternovelli.com.

More on gut microbiome influences on depression

10月

24日

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The influence of genetic variation on the rate of depression ranges from 37% to 48%, showing a strong relation between family history and depression. The gut microbiome can be a promising approach for managing depression.

Gut dysbiosis is associated with major depressive disorder (MDD) by involvement with various aspects of Gut-brain axis (GBA). It promotes neuroinflammation and causes behaviour alteration, according to the September 07, 2022 Science Direct report.

There are three diet metabolites - kynurenine, tryptophan, and propionic acid - that greatly influence the activities of the gut microbiome and the deficiencies of which can contribute to depression. Researchers found that depression disorder also shows gut-brain dysregulation, an increase in inflammatory cytokines in the blood of depressive patients, dysregulation in fatty acid metabolism, neuropeptide, gut hormone and neurotransmitter synthesis, and abnormal immune system activation, as reported by Science Direct.

https://www.sciencedirect.com/science/article/abs/pii/S0166432822003497

Looking for specific microbes helps identify cancer; aids in early treatments

10月

14日

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Subhajyoti De, associate professor of cancer systems biology at Rutgers Cancer Institute of New Jersey together with RWJBarnabas Health, found that microorganisms may be new targets for earlier diagnosis or treatment of pancreatic cancer (1).

According to the October 10 2022 Rutgers University press release, they were able to identify tumor-associated microbes and measure the activity of the host cells at the same time. They examined the microbiome of pancreatic tumors and identified particular microorganisms that are associated with inflammation and poor survival (2).

Short of two weeks earlier, research by Lian Narunsky Haziza, a cancer biologist at the Weizmann Institute of Science in Israel, found that tumors contain millions of microbes and fungi, representing dozens of species, according to a September 29 2022 New York Times article (2).

So-called tumor microbiome is proving so distinctive in each type of cancer that some scientists hope to find early signs of hidden tumors by measuring the microbial DNA they shed into the blood, says the study led by Dr. Haziza.

1) https://www.rutgers.edu/news/microorganisms-tumors-may-help-identify-new-approaches-treating-pancreatic-cancer

2) https://www.nytimes.com/2022/09/29/science/cancer-tumors-fungi-bacteria-microbiome.html

Healthy stool from fecal transplant in an IBS patient's digestive track reduces symptoms

9月

30日

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Stool with healthy microorganisms inserted into a person’s digestive tract has been shown to reduce abdominal stress and tiredness in patients with irritable bowel syndrome (IBS), according to a September 13, 2022 article in Everyday Health.

The efficacy of this inexpensive treatment has shown to last three years for over 90% of patients, and beyond three years for over 70% of patients, according to the report by author Magdy El-Salhy, MD, a gastroenterologist at Stord Helse Fonna Hospital in Norway. Her team found that dysbiosis, a gut micriobiome imbalance, was lower among those receiving active treatment after two to three years.

https://www.everydayhealth.com/ibs/fecal-transplant-provides-relief-from-irritable-bowel-syndrome-symptoms/

Adaptive Biotech gets creative with financing

9月

24日

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A worthwhile digression from Herbsprout’s standard health topics, Seattle-based biotech Adaptive Biotechnologies Corp. (Nasdaq: ADPT) came up with up to $250 million in innovative/ creative financing during the current economic downturn. The deal mix of business development revenue share with financing.

According to a September 14 2022 Puget Sound Business Journal report, the company inked a royalty financing agreement with health care investment firm OrbiMed. Adaptive is developing an immune system platform to build a data-driven, “clinical-product development engine”. With the immune system as the “source code”, Adaptive says it can develop diagnostics and therapeutics for almost any disease, according to the company.

Through the agreement, Adaptive will receive an initial $125 million in exchange for OrbiMed receiving 5% of Adaptive's revenue. Adaptive can receive an additional $75 million for 8% of its revenue and another $50 million, earmarked for potential merger and acquisition deals, for 10%.

"This was a really nice creative structure because for us, we didn't want to raise equity capital and dilute the shareholder base when our stock is trading significantly below historical levels," said Chad Robins, co-founder and CEO of Adaptive is quoted Puget Sound Business Journal. “Debt will have a balloon payment or an amortization where if for any reason the markets aren't there and you can't recapitalize or you can't repay that debt, that provides a lot of risk to a company."

Adaptive will have to pay OrbiMed back 1.65 times whatever it takes, but the rate decreases if Adaptive can pay the firm back in 18 or 24 months, Robins said. He added that although there is a $50 million tranche reserved for M&A, Adaptive isn't targeting anything specific right now. According to Robins, the company will lay out a path to profitability in its third quarter earnings, and this money will help Adaptive reach that goal without having to raise equity capital.

https://www.bizjournals.com/seattle/inno/stories/fundings/2022/09/14/adaptive-royalty-financing-agreement-orbimed.html

Sleep Apnea underdiagnosed in connection to cardiovascular diseases

9月

18日

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Obstructive sleep apnea (OSA) is one of the most common and serious sleep-related breathing disorders with a strong connection to patients with cardiovascular (CV) diseases.

Despite its prevalence, OSA is often underdiagnosed and untreated, even though it can increase risk of heart failure, arrhythmias, hypertension, and coronary artery disease, according to an August 11 2022 report by Handawi journal. The report claims that sleep apnea occurs in more than 40% of CV patients.

In addition to CV diseases, sleep apnea can result in repetitive upper airway collapse during sleep and insufficient oxygen.

https://www.hindawi.com/journals/cdtp/2022/6006127/

treating depression by supporting our gut microbiome

9月

10日

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The gut microbiome can be a promising approach for the management of depression. A September 7, 2022 Science Direct report suggest that the gut microbiota control the host epigenetic machinery in depression.

Gut dysbiosis causes negative epigenetic modifications via mechanisms like histone acetylation, DNA methylation and non-coding RNA mediated gene inhibition.

The diet and dietary metabolites like kynurenine, tryptophan, and propionic acid also greatly influence the microbiome composition and the physiological activities.

Science Direct point out that stress is one of the important risk factors for depression that results from chronic or early life stress, in the range of 37% to 48% showing a strong relation between family history and depression.

https://www.sciencedirect.com/science/article/abs/pii/S0166432822003497