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“WHERE THINGS SO SMALL CAN HAVE A MASSIVE IMPACT ON YOUR HEALTH.”
Herbsprout is a webblog and podcast dedicated to sharing the health benefits of herbs, food, innovations related to our gut microbiome. Herbsprout seeks to bridge the vast chasm dividing the mainstream medical community and alternative medicine.

人間は微生物叢にとっては「サンゴk礁」ですあることは病気を予防する多様性の鍵となる; Humans are “coral reefs” for microbiota; diversity key to disease prevention

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人間は微生物叢にとっては「サン...
人間は人間の DNA よりも細菌の DNA の方が多いという声明が飛び交っています。細菌細胞 (38 兆) 対人間細胞 (30 兆)(2)、または細菌遺伝子 (3,000 万) 対人間遺伝子 (23,000) (1)など、どのように切り取っても、その結果は、人体が「サンゴ礁」のような腸内微生物の生態系であることを示しています。

このアイデアは、エル・パイス誌(2)の2023年2月26日号で有名な微生物学者フレデリック・ブッシュマンによって名付けられました。あるいは、微生物学者のイグナシオ・ロペス=ゴニが言うように、「私たちはゲノムの 1% が両親から、99% が微生物(1)から受け継がれた超生物です」

研究者や健康専門家は、人間の「サンゴ礁」の中に今日の健康上の問題の多くの原因があり、今日の非常に多くの解決策の源があると確信しています。

腸内微生物のほとんどの菌株は有益で健康的ですが、他の菌株は有害であるあることが特定されています。イェール大学の研究者達による最近の研究では、モルガネラ・モルガニイと大腸菌が人間のDNAに対して有毒な分子を生成し、ネズミの研究でも腫瘍を引き起こすことが判明した。胃内でよく見付かる別の細菌であるヘリコバクター・ピロリは、胃がんのリスク増加(3)と関連しています。

一方では、「ほとんどすべての病気の共通要因は[微生物叢の]多様性の喪失であり、これはおそらく、野菜をほとんど含まないタンパク質と脂肪の豊富な食事にも関連していると考えられます」。エル・パイス誌(1)2023年1月2日号に引用されている、国際ヒューマンマイクロバイオームコンソーシアム科学委員会メンバーである消化器科医フランシスコ・ガーナーによると、野菜を消化するために結腸内に存在していた微生物叢は失われるし、消滅する。

国立衛生研究所のPubMedは、複数世代にわたり、低繊維、低MAC(微生物叢がアクセス可能な炭水化物)食生活は多様性の進行性の喪失をもたらし、MAC食生活を再導入しても、それを元に戻すことはできません。食物繊維に含まれるMACは、この微生物生態系の形成に重要な役割を果たしており、伝統的な食生活と比較して西洋の食生活では著しく減少しています。(5)

東京の医薬基盤研究所の黒谷佳代氏は、高繊維納豆は大豆を枯草菌で発酵させて作られ、味噌は大豆を麹菌で発酵させて作られることを発見した。93,000人の日本人と彼らの食習慣を対象とした同氏の研究では、納豆を最も多く食べる男性はほとんど食べない男性に比べて死亡率が24%低く、女性は心血管疾患による死亡リスクが21%低いことが示された。(3)

 

1) https://english.elpais.com/science-tech/2023-01-03/we-are-half-human-half-bacteria-what-the-microbes-in-our-bodies-can-do-for-us.html

2) https://english.elpais.com/science-tech/2023-02-26/study-reveals-exchange-of-microbiome-bacteria-could-increase-risk-of-disease.html?outputType=amp

3) https://www.reuters.com/article/us-health-diet-soy/miso-soup-might-be-one-comfort-food-that-helps-you-live-longer-idUSKBN2012J6

4) https://english.elpais.com/science-tech/2022-10-31/gut-dwelling-bacterium-singled-out-as-the-possible-cause-of-colorectal-cancer.html

5) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850918/

その他の関連記事: https://www.cnbc.com/2023/03/02/nutritionist-from-japan-shares-foods-she-eats-every-day-to-stay-healthy-young-and-live-longer.html

 The statement has been tossed around that people have more bacterial DNA than human DNA. However you slice it, whether by bacteria cells (38 trillion) versus human cells (30 trillion) (2) or bacteria genes (30 million) versus human genes (23,000) (1), the results points toward the human body as an ecosystem of gut microbes, like a “coral reef”.

This idea is dubbed by famous microbiologist Frederick Bushman in a February 26 2023 issue of El Pais (2). Or as microbiologist Ignacio López-Goñi puts it, “We are superorganisms in which 1% of our genome is inherited from our parents and 99% from our microbes (1).”

Researchers and health experts are convinced that inside the human “coral reef“ are causes of so many of today’s health problems, and source of so many of today’s solutions.

While most strains of gut microbes are helpful and healthy, others have been identified as harmful. A recent study by researchers at Yale University found that Morganella morganii and Escherichia coli produce molecules that are toxic to human DNA, also causing tumors in a mice study. Another common bacterium in the stomach, Helicobacter pylori, is associated with an increased risk of gastric cancer (3).

On the other hand, “The common factor…in almost all diseases is the loss of diversity [in the microbiota], which is possibly also related to protein- and fat-rich diets [that include] few vegetables. The microbiota that we had in the colon to digest those vegetables is lost and disappears,” according to gastroenterologist Francisco Guarner, a member of the International Human Microbiome Consortium’s scientific committee who is quoted in the January 2 2023 issue of El Pais (1).

The National Institute of Health’s PubMed reported that over multiple generations, a low-fiber, low-MAC (Microbiota accessible carbohydrates) diet results in a progressive loss of diversity, which is not recoverable upon the reintroduction of dietary MACs. MACs found in dietary fiber, play a key role in shaping this microbial ecosystem, and are strikingly reduced in the Western diet relative to more traditional diets (5).

Kayo Kurotani of the National Institutes of Biomedical Innovation in Tokyo, found that high fiber Natto is made from soybeans fermented with Bacillus subtilis, and miso is soybeans fermented with Aspergillus oryzae. His study of 93,000 Japanese and their eating habits showed that men who ate the most natto were 24% less likely than those who rarely ate, and women were a 21% lower risk of dying from cardiovascular causes (3).

1) https://english.elpais.com/science-tech/2023-01-03/we-are-half-human-half-bacteria-what-the-microbes-in-our-bodies-can-do-for-us.html

2) https://english.elpais.com/science-tech/2023-02-26/study-reveals-exchange-of-microbiome-bacteria-could-increase-risk-of-disease.html?outputType=amp

3) https://www.reuters.com/article/us-health-diet-soy/miso-soup-might-be-one-comfort-food-that-helps-you-live-longer-idUSKBN2012J6

4) https://english.elpais.com/science-tech/2022-10-31/gut-dwelling-bacterium-singled-out-as-the-possible-cause-of-colorectal-cancer.html

5) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850918/

Other related articles: https://www.cnbc.com/2023/03/02/nutritionist-from-japan-shares-foods-she-eats-every-day-to-stay-healthy-young-and-live-longer.html

ワオ!と言っているユーザー

Gut health benefits of Brazilian fruits

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Gut health benefits of Brazilian ...

Plant-based diets, rich in antioxidants and anti-inflammatory compounds, are key to prevention non-communicable chronic diseases (NCD), says the Multidisciplinary Digital Publishing Institute (MDPI) in a September 19, 2023 issue (1).


NCDs like cardiovascular diseases, obesity, diabetes, and cancer stem from genetic, environmental, and behavioral factors and are aggravated by high-sugar, high-fat diets (3).


Brazilian native fruits, originating from diverse biomes, are rich in bioactive compounds, and their processing not only allows for fresh consumption, but also yields by-products rich in valuable elements like phenolics, providing substantial health benefits. According to the National Institute of Health, phenolics in plants can defend against ultraviolet radiation, pathogens and parasites (2). Brazilian native fruits include acerola, açaí, baru, buriti, guava, jabuticaba, and juçara. Cerrado plants present in the Brazilian forests, contain phenolic compounds which offer anti-inflammatory and antimicrobial actions (4). 


The MDPI review discusses the findings of in-vitro studies, pre-clinical studies and clinical trials on the effects of Brazilian native fruits, their by-products, as well as their bioactive compounds on human intestinal microbiota and NCD showing the science behind these claims (1).


1. https://www.mdpi.com/2304-8158/12/18/3491


2. https://www.news-medical.net/news/20230921/Brazilian-fruits-positively-impact-gut-health-and-chronic-disease-prevention.aspx


3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259146/#:~:text=Plant%20phenolics%20are%20generally%20involved,part%20of%20the%20human%20diet.


4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4632725/


ワオ!と言っているユーザー

TCM’s Astragalus plant keys longevity & cancer prevention

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TCM’s Astragalu...

The astragalus plant (Astragalus membranaceus) has been used in Traditional Chinese Medicine (TCM) for thousands of years. It was often combined with other herbs to strengthen the body against disease. Astragaus is an adaptogen that defends our body from physical, mental, or emotional stress (1).

Astragalus is important in the aging process, and research suggests, has positive effects on tumors and cancer, according to Pubmed Central (4) and Oxford University Press.

Astragalus helps prevent tumor growth and protects against cell damage. Astragalus achieves this by reducing the aging of telomeres. Telomeres are structural “protective ends” of DNA. Telomere attrition during successive cell divisions induces chromosomal instability, and can lead to cancer. Cancer is generally an age-related genetic disease, manifesting only when normal cells accumulate genomic instability over a period of time, according to Biomed Central (3).

One study of 29 human colon cancer cells and tumor xenograft was undertaken by Quality Assurance Laboratory of the School of Chinese Medicine and Hong Kong Baptist University (6). The results showed that Astragalus saponins (AST) inhibit cell proliferation in part by inhibiting cyclin-dependent kinase activity, according to the research published by Oxford University Press (6).

Other sources say that Telomeres are a ribonucleoprotein complex responsible for progressive synthesis of telomeric DNA repeats (TTAGGG) (3). Telomerase counteracts the telomere shrinking process that delays, even reverses the cellular aging process (4) (5).

1. https://www.medicalnewstoday.com/articles/astragalus-benefits

2. https://www.sciencedirect.com/topics/medicine-and-dentistry/astragalus

3. https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-016-0324-x

4. https://pubmed.ncbi.nlm.nih.gov/21417995/#:~:text=Telomerase%20is%20the%20enzyme%20responsible,and%20stem%20and%20tumor%20cells

5. https://en.m.wikipedia.org/wiki/Telomerase

6. https://academic.oup.com/carcin/article/28/6/1347/2476243#


ワオ!と言っているユーザー

study of Japanese gut microbiome reflects unique dietary habits; 独特の食習慣を反映している日本人の腸内微生物叢の研究

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study of Japane...

日本人は⻄洋人と比べて独特の食文化と習慣を持っており、赤身の肉よりも魚介類を食 べることに強調しています。研究者は、彼らの腸内微生物叢には、水生植物由来の多糖 類を分解する酵素の遺伝子がアメリカ人よりも多く存在していることを発見した。国立 衛生研究所、パブメド・セントラルの報告書によると、日本人は平均寿命が最も⻑く、 体格指数(BMI)が非常に低い。
この研究では、NGS (次世代シーケンス) を使用した糞便 DNA サンプルのシーケンスに より、日本人 106 人の腸内微生物叢からメタゲノム データを収集および分析されまし た。そして、日本を含む 12 カ国から選ばれた合計 861 人の健康な個人からの腸内微生 物叢のデータを使用し、JPGM(日本の腸内微生物叢)のユニークな微生物および機能 的特徴をさらに調査されました。
細菌門の存在量を比較すると、JPGM は放線菌の存在量が最も多いことを示しました。 放線菌は、抗生物質、抗真菌物質、および抗がん剤の特質を持つ二次代謝産物を生成し ます。
対照的に、JPGM におけるバクテロイデテス属とプロテオ細菌の存在量は他のさまざま な国の微生物叢よりも非常に低かった。それは代謝障害や炎症性腸疾患が関与されてい ると考えられています。
属レベルでは、JPGM はビフィズス菌、ブラウティア、コリンセラ、連鎖球菌、および 未分類のクロストリジウム属が最も豊富に含まれていることを特徴としていましたが、 クロストリジウム、アリスティペス、未分類のファーミクテス、ダイアリスター、ブチ リビブリオの存在量は 12 か国の中で最も少ない。


Japanese (JP) have unique dietary culture and habits compared with Western people, with an emphasis on consuming seafood over red meat. Researchers connect the dots that their gut microbiomes have more genes for aquatic plant-derived polysaccharide-degrading enzymes than those of Americans, for example. Japanese exhibit the highest average life span and very low body mass index (BMI), according to a report by Pubmed Central, National Institute of Health. 


The study collected and analysed the metagenomic data from gut microbiomes of 106 Japanese individuals by sequencing of fecal DNA samples using NGS (next generation sequencing), and further explored the unique microbial and functional features of the JPGM (Japanese gut microbiome) using microbiome data from a total of 861 healthy individuals selected from 12 countries, including Japan.
When comparing the abundance of the bacterial phyla, the JPGM showed the highest abundance of Actinobacteria. Actinobacteria produce secondary metabolites that have antibiotic, antifungal, and anticancer qualities (2). In contrast, the abundance of Bacteroidetes and Proteobacteria in the JPGM was significantly lower than in the microbiomes of various other countries, which are believed to involve metabolic disorders and inflammatory bowel disease (3). 
At the genus level, the JPGM was characterized by the highest abundance of Bidfidobacterium, Blautia, Collinsella, Streptococcus, and unclassified Clostridiales, but the lowest abundance of Clostridium, Alistipes, unclassified Firmicutes, Dialister, and Butyrivibrio among the 12 countries.


1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833420/


2. https://www.nps.gov/articles/actinobacteria.htm#:~:text=Actinobacteria%20produce%20secondary%20metabolites—organic,%2C%20antifungal%2C%20and%20anticancer%20qualities 


3. https://pubmed.ncbi.nlm.nih.gov/29230419/#:~:text=Several%20studies%20demonstrate%20an%20increased,disorders%20and%20inflammatory%20bowel%20disease.

ワオ!と言っているユーザー

Fecal microbiome inadequately represents gut microbiome

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Fecal microbiome inadequately...
While fecal sampling is the current standard for representing the whole human gut microbiome, fecal microbiome is insufficient to represent the whole gut microbiome of the GI tract in a recent study of pigs, according to Hindawa Cellular Biology January 17 2023 issue.

For one, stool consistency varies over time. In addition, both gut microbiome composition and phenotypes or diseases of interest help define the nature of one’s health. Researchers then found a significant compositional difference of gut microbiome by specific location along the GI tract. All this calls for greater accuracy than exclusively using stool samples as a means for determining gut health and gut research.

https://www.hindawi.com/journals/cmi/2023/6868417/

ワオ!と言っているユーザー

Links in relationships also link gut bacteria

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Links in relationships also link...
In the last Herbsprout blog, we learned about the interchange of gut microbes between pets and their owners. This blog is taken from Psychology Today. Though lacking the scientific references, one can safely assume what applies to humans and their pets also applies person to person.

We begin with proximity. Proximity to peers plays a role in the microbial content of our gut. Gut microbiome links in family relationships begin at early childhood when the mother’s microbiome influences the gut microbiota of the baby, and continues throughout life, according to an August 09 2023 article in Psychology Today.

People who live with us or are relatively close to us impact the shape of our gut, skin, and oral microbiomes, say the Psychology Today article. This includes family members, friends, and neighbors (1).

Diseases associated with microbiome dysfunction, including obesity, type 2 diabetes, and cognitive disorders, could be influenced by the microbiomes of those around us.

For instance, some diseases that were not previously found communicable have now been considered to be at least partially communicable, such as diabetes or inflammatory bowel disease (1).

The downside of these influences however, include antibiotic resistance that develops in a common community due in part to their micriobial commonalities, as warned by Alexander Fleming in 1945 in his Nobel acceptance speech (2).

1. https://www.psychologytoday.com/intl/blog/the-behavioral-microbiome/202308/microbiome-new-criteria-for-selecting-a-partner?amp

2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939477/

 

ワオ!と言っているユーザー

humans and pets exposed to each other’s gut microbiome show improvements to lifelong health

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humans and pets...
In a brand new area of research, people exposed to more furry pets and green space early in life have a lower risk of immune and allergic conditions later, according to Curtis Huttenhower, professor of computational biology and bioinformatics at Harvard T.H. Chan School of Public Health in his June 29, 2023 interview. He believes some of those effects are due to the microbiome from their pets. Likewise, pets too can benefit from exposure to the human gut microbiome, adds Huttenhower.

In partnership with the Pet Nutrition Center, because pets maintain consistent food consumption, the Center’s staff along with robotics track the specific types and amounts of food consumed by each individual animal, which includes a consistent diet compared to humans.

Huttenhower explains how the degree to which high-fiber diets help prevent inflammation depends on which gut microbes people have, which is why people respond to the same diet differently. “We all carry vastly different bugs in our microbiomes,” he adds.

The interchange of pet and human microbes presents the opportunity to acquire the “right” microbes at the “right” times leading to better lifelong health.

https://www.hsph.harvard.edu/news/features/gut-microbiome-of-pets-reveals-insights-for-human-health-curtis-huttenhower/

ワオ!と言っているユーザー

Machine learning of microbiome used to predict cancer

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Machine learning of microbiom...
Technology advances in DNA sequencing and more sophisticated data-analytics tools has led to extensive research on the relationship between the microbiome and diseases. Researchers are developing a machine learning-based approach to distinguish the type of cancer by analyzing the tissue-specific microbial information, according to the July 21, 2023 issue of Nature.com (1).

Random Forest models of five types of cancers from the Cancer Microbiome Atlas database, achieved promising performances when predicting head and neck, stomach, and colon cancer cases, with the latter showing 90% accuracy across the different studies conducted, says the Nature article. The random forest method forms multiple decision trees in machine learning by regression classification task outputs (2).

This research shows the potential of adopting machine learning techniques in predicting disease and cancer.

1. https://www.nature.com/articles/s41598-023-38670-0

2. https://en.m.wikipedia.org/wiki/Random_forest

 

ワオ!と言っているユーザー

腸を元気にする 6 つのハーブ; 6 herbs that heal the gut

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Dr. Nicole Apelian Dr. Nicole Apelian Lion’s mane mus... Lion’s mane mushroom

The following is part two by guest author Dr. Nicole Apelian. She was among the first women selected for the History Channel’s hit TV show “Alone”. She has B.S and M.S. degrees in Biology from McGill University in Canada and the University of Oregon. She earned her Doctorate through Prescott College.

腸を元気にする 6 つのハーブ

以下は、ゲスト著者であるニコールアペリアン博士によるパート 2 です。彼女は、ヒ ストリーチャンネルの人気テレビ番組「アローン」に選ばれた最初の女性の一人でし た。 彼女は、カナダのマギル大学およびオレゴン大学で生物学の学位を取得し、学士号と修 士号を持っています。彼女はプレスコット大学で博士号を取得しました。
私は、腸を癒し、健康な微生物叢を促進する 霊芝・ライオンのたてがみ・七面鳥の尾 の薬用キノコ・オオバコ・アスリッパリーニレ・マシュマロ、6 つの特別なハーブを使 用しています。この植物は、炎症を軽減し、重要なプレバイオティクスを提供し、腸の 再生と治癒を可能にする保護膜を腸内に形成するのに役立ちます。追加の利点は、以下 で説明します。

霊芝(Ganoderma lucidum)
霊芝は、炎症の増加・ホルモンの不均衡・高コルチゾール、疲労などのストレスによる 悪影響に対して身体を強化する優れたアダプトゲンハーブです。ストレスが炎症を引き 起こす可能性があるため、霊芝は 多発性硬化病の場合に特に重要です。また霊芝も若 返りの睡眠を促し、副腎の健康を促進し、健康な免疫反応をサポートします。さらに、 神経保護作用があり、アレルギーを鎮め、抗ウイルス作用もあります。
ライオンのたてがみ (Hericium erinaceus)

ライオンのたてがみキノコは、神経系を強化し、腸の炎症に対処するため、多発性硬化 症を管理するためのもう一つの優れた漢方薬です。また、ミエリン鞘として知られる神 経線維を取り囲む保護的な脂肪コーティングの修復に必要な神経成長因子の促進にも役 立ちます。多発性硬化症の患者の場合、ミエリン鞘は重度の損傷を受けていることがよ くあります。このタンパク質は、学習・記憶・集中力に関与するニューロンを維持しま す。 研究により、ライオンのたてがみは認知機能も改善する効果もあることが証明さ れています。
七面鳥の尾 (トラメテス癜風)
もう一つ抗炎症作用のある薬用キノコは七面鳥の尾です。また、免疫システムの活性が 過剰になったり、活性が低下したりしないように調節するにも役立ち、自己免疫を管理 するための優れた漢方薬になります。 さらに、この印象的なキノコは優れたプレバイオティクスでもあり、カンジダと闘い、 小腸細菌の異常増殖 (SIBO) に対処します。

冬虫夏草 (Cordyceps militaris)
私は多発性硬化症を管理するために、毎日冬虫夏草の抽出物も使用しています。霊芝と
同様に、冬虫夏草は何世紀にもわたって伝統的な中国医学で使用されていました。冬虫
夏草は多発性硬化症患者にとって重要な考慮事項である神経細胞死を減らす神経保護特
性があることが知られています。このユニークなキノコは抗炎症作用があり、エネルギ
ーの改善に役立ちます。
また冬虫夏草は、抗菌性・抗バクテリア・抗ウイルス・抗真菌剤、抗原虫作用もあり、
腸の健康状態不良に対処するのに役立ちます。冬虫夏草は抗がん作用があり、血糖値も
調節する効果があります。最後に、オオバコ・アスリッパリーニレ・マシュマロの根が
炎症を鎮め、粘膜を落ち着かせ、腸の再生を助ける保護層を形成します。私がこの植物
はリーキーガットの治癒に不可欠であることがわかりました。
 天然ハーブと治療法についてさらに詳しく知りたい場合は、ニコール・アペリアン博士
 の著書『The Lost Book of Herbal Remedies: The Healing Power of Plant
 Medicine』をここから入手できます。
 割引料金で購入するには、チェックアウト時にクーポン WELCOME10 を使用し、最初の 注文から 10% オフにしてください。ニコールが日常的に多発性硬化症をどのように管
 理しているかについては、彼女の詳細ブログをお読みください。 ありがとう!
 • 霊芝は血管拡張作用があるため、出血性疾患のある方や手術前の使用は禁忌で す。
 ** Mase G. (2012)。 薬用キノコ: 主要な種の簡単な歴史と概要。2016 年 8 月
27 日に http://www.vtherbcenter.org/wp-
  content/uploads/2012/04/Medicinal-Mushrooms.pdf
   より取得する。
 • この記事の内容は情報提供のみを目的とし、医学的アドバイスを構成するもので
 はなく、診断や治療の代替を意図したものではないことにご注意ください。病状
に関する質問がある場合は、必ず資格のある医療提供者のアドバイスを求めてく
 ださい。この Website を読んだことを理由にして、専門の医学的アドバイスを
 無視したり、アドバイスを求めるのを遅らせたりしないでください。医療上の緊
 急事態が発生した場合は、直ちに医師または 911 に電話してください。 この
 Website が提供する情報を信頼する場合は、お客様ご自身の責任で行ってくださ
い。
 • ニコール・アペリアン博士は、薬草医・母親・サバイバルスキルのインストラク
 ター・人類学者・生物学者です。彼女はカナダのマギル大学およびオレゴン大学
で生物学の学位を取得し、学士号と修士号を持っています。彼女はボツワナで人
類学者および民族植物学者として働きながらプレスコット大学で博士号を取得し
 ました。

 彼女は、今も狩猟採集民として暮らしている最後の先住民族のひとつであるカラ
 ハリ砂漠のサン・ブッシュマンたちと一緒に自然の中で何年も暮らしてきまし
た。
 部族内で強い関係を現像することで、ニコールは現在実践し教えている治療法や
 スキルの多くを学び、非営利団体「The Origins Project」を通じてサン族との
 活動を続けています。
 2000 年に多発性硬化症と予期せぬ診断を受け、ニコールは自分の研究スキルを
 自分自身の健康に応用することになりました。彼女は、深い自然とのつながりや
 感謝の習慣など、健康的な生活戦略に焦点を当てました。ライフスタイルを変
 え、心と体の深いつながりを認識し、独自の治療法を作成して使用することによ
 って、ニコールは寝たきりから完全に生き、生存から繁栄へと成長しました。
 彼女は、苦しんでいるたくさんの人々が自分自身の治療法を見つける必要がある
 と信じています。
 これが彼女の人生の使命となり、著書『The Lost Book of Herbal Remedies:
 The Healing Power of Plant Medicine』を執筆する主な理由となった。その中
 に彼女は 28 年以上にわたる植物の知識と、湿布・チンキ剤・煎じ薬・軟膏・注
 入油、その他のハーブ療法を自分で作った直接の経験を注ぎ込みました。
 2015 年、彼女はヒストリー チャンネルの人気テレビ番組「アローン」に史上初 めて選ばれた女性の一人でした。多発性硬化症を患っていたにも関わらず、彼女 は狩猟用ナイフとそこで見つけた野生の食べ物と薬だけを持って、バンクーバー
 島の人里離れた地域で 57 日間連続で一人で生き続けた。
 ニコール・アペリアン博士について詳しくは、こちらをご覧ください。
https://nicoleapelian.com/. https://www.instagram.com/ nicole_apelian/https://www.facebook.com/nicoleapelian survival/


I use six specific herbs that heal the gut and promote a healthy microbiome: reishi, lion’s mane, and turkey tail medicinal mushrooms, along with plantain, slippery elm, and marshmallow. These botanicals help to calm inflammation, provide important prebiotics, and create a protective coating in the gut that allows it to regenerate and heal. They also have additional benefits, which we will explore below.

Reishi (Ganoderma lucidum)
(Link for reishi photo: https://nicolesapothecary.com/products/reishi-mushroom-tincture)
Reishi mushroom is an outstanding adaptogenic herb that strengthens the body against the negative effects of stress — such as increased inflammation, hormonal imbalance, high cortisol, and fatigue. This is particularly important if you have MS because stress can cause a flare. Reishi also encourages rejuvenating sleep, promotes adrenal health, and supports a healthy immune response. Moreover, it is neuroprotective, calms allergies, and is antiviral.
Lion’s Mane (Hericium erinaceus) (Link for lion’s mane photo:
https://nicolesapothecary.com/products/lions-mane-mushroom-tincture)
Lion’s mane mushroom is another impressive herbal medicine for managing MS as it fortifies the nervous system and addresses gut inflammation. It also helps to encourage Nerve Growth Factor (NGF), which is necessary for the repair of the protective, fatty coating surrounding nerve fibers known as the myelin sheath. For those with MS, the myelin sheath is often severely damaged. This protein maintains the neurons that are involved in learning, memory, and focus. Research has
established that lion’s mane also improves cognitive function.
Turkey Tail (Trametes versicolor)
(Link for turkey tail photo: https://nicolesapothecary.com/products/turkey-tail-mushroom-tincture)
Another anti-inflammatory medicinal mushroom is turkey tail. It also helps to modulate the immune system so that it is not over or under active, making it an excellent herbal remedy for managing autoimmunity. Turkey tail is exceptional for healing leaky gut, chronic fatigue syndrome, and treats a range of bacterial and viral infections as well. What’s more, this impressive mushroom is also an outstanding prebiotic, combats candida, and addresses small intestinal bacterial overgrowth (SIBO).
Cordyceps (Cordyceps militaris) (Link for cordyceps photo:
https://nicolesapothecary.com/products/cordyceps-mushroom-tincture)
Additionally, I use a cordyceps extract everyday to manage my MS. Similar to reishi, cordyceps has been used in Traditional Chinese Medicine for centuries. It is known to have neuroprotective properties that reduce neuronal cell death — an important consideration for those with MS. This unique mushroom is anti-inflammatory and helps to improve energy. It is also antimicrobial, antibacterial, antiviral, antifungal, and antiprotozoal, which is helpful for addressing poor gut health. Cordyceps is anti-cancer and regulates blood sugar as well.

Lastly, plantain, slippery elm, and marshmallow root calm inflammation, soothe mucous membranes, and create a protective layer that helps the gut to regenerate. I have found these botanicals to be essential for healing leaky gut.

If you would like to learn more about natural herbs and remedies, Dr. Nicole Apelian’s book, The Lost Book of Herbal Remedies: The Healing Power of Plant Medicine, is available here.
For access to Nicole’s Apothecary at a discounted rate, please use the coupon WELCOME10 at checkout for 10% off your first order. To learn how Nicole manages her MS on a daily basis, please read her detailed blog on this subject. Thank you!

Reishi is a vasodilator, so it is contraindicated for those with a bleeding disorder or for use before surgery. **Masé, G. (2012). Medicinal mushrooms: A brief history and overview of principal species. Retrieved on 08/27/2016 from http://www.vtherbcenter.org/wp-content/uploads/2012/04/Medicinal-Mushrooms.pdf

Please note that the contents of this article are for informational purposes only, do not constitute medical advice, and are not intended to be a substitute for diagnosis or treatment. Always seek the advice of a qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website. In the event of a medical emergency, call a doctor or 911 immediately. Reliance on any information provided by this website is solely at your own risk.
Nicole Apelian, Ph.D.

Dr. Nicole Apelian is an herbalist, a mother, a survival skills instructor, an anthropologist, and a biologist. She has B.S and M.S. degrees in Biology from McGill University in Canada and the University of Oregon. She earned her Doctorate through Prescott
College while working as an anthropologist and ethnobotanist in Botswana.
She has spent years living in nature with the San Bushmen of the Kalahari Desert, one of the last indigenous peoples who still live as hunter-gatherers. Developing strong relationships within the tribe helped Nicole learn many of the remedies and skills she practices and teaches today and she continues her work with the San through her non-profit, “The Origins Project“.
An unexpected diagnosis of multiple sclerosis in 2000 led Nicole to apply her research skills towards her own personal wellness. She focused on a healthy living strategy, including deep nature connection and gratitude practices. Through changes in her lifestyle, recognizing profound mind-body linkages, and making and using her own remedies, Nicole went from bedridden to being fully alive and from surviving to thriving.
She believes that there are many more people suffering who need to find their own remedy. This became her life’s mission and the main reason for writing her book The Lost Book of Herbal Remedies: The Healing Power of Plant Medicine. In it she poured over 28 years of plant knowledge and her first-hand experiences of making her own poultices, tinctures, decoctions, salves, infused oils, and other herbal remedies.
In 2015 she was among the first women ever selected for the History Channel’s hit TV show “Alone”. Despite having MS, she went on to survive solo for 57 days straight in a remote area of Vancouver Island with little more than her hunting knife and the wild foods and medicines she found there.
For more about Dr. Nicole Apelian please visit https://nicoleapelian.com/. https://www.instagram.com/nicole_apelian/https://www.facebook.com/nicoleapeliansurvival/

 
References: 
Philip, A., & White, N. D. (2022). Gluten, Inflammation, and Neurodegeneration. American journal of lifestyle medicine, 16(1), 32–35. https://doi.org/10.1177/15598276211049345
Esmaeil Amini, M., Shomali, N., Bakhshi, A., Rezaei, S., Hemmatzadeh, M., Hosseinzadeh, R., Eslami, S., Babaie, F., Aslani, S., Torkamandi, S., & Mohammadi, H. (2020). Gut microbiome and multiple sclerosis: New insights and perspective. International immunopharmacology, 88, 107024. https://doi.org/10.1016/j.intimp.2020.107024
Jangi, S., Gandhi, R., Cox, L. et al. Alterations of the human gut microbiome in multiple sclerosis. Nat Commun 7, 12015 (2016). https://doi.org/10.1038/ncomms12015
Shahi, S. K., Freedman, S. N., Murra, A. C., Zarei, K., Sompallae, R., Gibson-Corley, K. N., Karandikar, N. J., Murray, J. A., & Mangalam, A. K. (2019). Prevotella histicola, A Human Gut Commensal, Is as Potent as COPAXONE® in an Animal Model of Multiple Sclerosis. Frontiers in immunology, 10, 462. https://doi.org/10.3389/fimmu.2019.00462

#diet #gutbacteria #gutbrainaxis #guthealth #gutmicrobiome #healthinnovation #microbiome #mindbody #naturopathichealth #nutrition #plantnutrition #spices #wellness
Which type of mushrooms do you regularly eat?

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Unprecedented Ai/ 3D mapping of brain and body

スレッド
Unprecedented Ai/ 3D mapping ...
Researchers from the Ludwig-Maximilians Universität München (LMU) and the LMU University Hospital developed a new method called wildDISCO that 3D maps the entire structures of the body using fluorescent markers, according to a July 10, 2023 article in Phys.org.

LMU scientists Dr. Ali Ertürk, Dr. Hongcheng Mai and Dr. Jie Luo mapped mouse body atlases, including the nervous system, protein expression, lymphatic vessels, blood vessels, and immune cells.

Ai integration enables details of complex biological systems. The team already discovered the integral role the gut microbiome plays in the development of the enteric nervous system.

The scientists believe it will reduce reliance on animal testing, while increasing efficiency of understanding diseases and developing new treatments.

https://phys.org/news/2023-07-wilddisco-visualizing-bodies-unprecedented.html

 

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