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In a recent study of mice published in Nature March 31 2025, found that microbiome is associated with multiple “health parameters, including body composition, immune components and frailty, but not lifespan.”

 

The study analysed 2,997 metagenomes collected from 913 genetically diverse mice. They investigated interactions between the microbiome, ageing, dietary restriction (caloric restriction and fasting), host genetics and a range of health parameters.

 

They found that the majority of microbiome features show small but significant connection to inherited genetic factors, and the amount of variation explained by host genetics is similar to ageing and dietary restriction.

 

We also find that while dietary interventions lead to larger microbiome changes and dietary restriction does not rejuvenate the microbiome, but not longevity.