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HerbSprout Microbiome Blog -

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“WHERE THINGS SO SMALL CAN HAVE A MASSIVE IMPACT ON YOUR HEALTH.”
Herbsprout is a webblog and podcast dedicated to sharing the health benefits of herbs, food, innovations, and our gut microbiome. Herbsprout seeks to bridge the vast chasm dividing the mainstream medical community, alternative medicine, and Asian medicine, especially of China (TCM), India (Ayurveda), and Japan (eJim & Kampo).

Ancient toilets hint of original human gut microbiome

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source: dreamstime.com source: dreamstime.com
An October 06 2020 article by the Archaeological Institute of America had an interesting story about toilets from days long past? Microbiome found in the latrines of medieval period Jerusalem and Riga Latvia show similarity to modern hunter gatherer microbiomes and modern industrial microbiomes,” according to Susanna Sabin of the Max Planck Institute for the Science of Human History quoted in the article. However they are slightly different possessing their own unique characteristics.

These findings may help us understand the originating microorganisms of the human gut before the widespread use of antibiotics and processed foods.

https://www.archaeology.org/news/9080-201006-medieval-human-microbiome

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Another potential disease prevention tied to gut microbiome and SCFAs

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Another potential disease preve...
A September 30 2020 Genetic Engineering and Biotechnology News article reported that Keio University School of Medicine's Dr. Hitoshi Tsugawa may have found a new approach to disease prevention. Tsugawa's study of mice demonstrated interaction between an immune cell protein, short-chain fatty acids (SCFAs), and gastrointestinal bacteria in our gut. The interaction triggers protection against Salmonella infection.

Some of the gut microbial species inside our gut can break down fiber eaten as part of the diet into short-chain fatty acids, which protect against the potential infections such as Shigella, E. Colin, and Salmonella, the report said. The study also examined how SCFA receptors contribute to the regulation of innate immune responses.

Tsugawa's team found that the SCFAs could bind to a protein called apoptosis-associated speck-like protein (ASC) to, prevent the inflammatory process. ASC is part of an inflammasome complex, which helps to activate the inflammatory response.

https://www.genengnews.com/news/dietary-fiber-gut-microbiome-and-immune-cells-work-together-to-prevent-infection/

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Impact of microbiota, heat and aging bones

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Impact of microbiota, heat and ...
On September 11 2020, Medical Express reported that a research team from the University of Geneva (UNIGE), Switzerland, observed that bone strength is enhanced by exposure to warmer ambient temperatures (34 °C). They also observed how temperature affects gut bacteria.

When microbiomes need to adapt to heat, it leads to a disruption in the synthesis and degradation of polyamines, molecules that are involved in aging, and in particular in bone health, according to the article.

https://medicalxpress.com/news/2020-09-stronger-bones-microbiota.amp

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Changing dynamics of gut microbiome in IBD patients

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Changing dynamics of gut micr...
Dr. Janst Jansson and colleagues of the Pacific Northwest National Laboratory determined the composition of the gut microbiomes in over 100 patients with inflammatory bowel disease (IBD) in three month intervals to determine how these microbiomes differ over time.

They found that IBD patients experienced erratic fluctuations in their gut microbiomes when compared to healthy individuals, which offers a valid way to monitor IBD patients. These fluctations appear to be correlated with the level of medications used by the patients.

As studies like these tend to do, it calls for medication- specific studies of positive and/or negative influences of each medication on the human gut microbiome. It may answer questions such as, "how are medications affecting these gut microbiome fluctuations?"

https://m.youtube.com/watch?v=oS1ZmFFSBtM

https://pubmed.ncbi.nlm.nih.gov/28191884/

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Study: gut bacteria to reduce allergies

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Study: gut bacteria to reduce a...
A September 14 2020 Genetic Literacy Project reported various findings that point to a potential gut microbiome solution to allergies. Researchers have spent decades on this concept called oral immunotherapy, which has come into use as a treatment for food allergies. Allergies affect an estimated 32 million people in the United States, including about two schoolchildren per classroom.

In March, scientists discovered large amounts of antibodies against peanut allergens in the stomach and gut of allergic patients, according to the Genetic Literacy Project article. Dr. Cathryn Nagler, immunologist at the University of Chicago, discovered the allergic mice lacked the normal communication that takes place between gut microbes and immune cells. Honing in on the specific gut bacteria strains, her team found that Clostridia, but not Bacteroides, prevented food-allergic responses.

Another study led by Rima Rachid and Talal Chatila at Boston Children’s Hospital, found that the single species Subdoligranulum variabile and a set of Clostridia species, including Anaerostipes caccae, prevented allergic responses. In both studies regulatory T cells were key to the response with the microbes triggering the response. Researchers found that by adding healthy microbes to allergic mice showed results in preventing the allergic reactions in those mice.

https://geneticliteracyproject.org/2020/09/14/do-you-have-food-allergies-manipulating-the-gut-microbiome-might-treat-them/

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Fungi linked to cognitive impairment can be aided by keto diet

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Fungi linked to cognitive impai...
According to an August 2020 NeuroScience article, scientists say the keto diet has an unique ability to help regulate fungi living with the gut bacteria of patients with mild cognitive impairment (MCI). The principal investigator of this research Hariom Yadav is assistant professor of molecular medicine at Wake Forest School of Medicine, of Wake Forest Baptist Health.

Yadav and his team tested the rRNA TS1 gene in 11 individuals, 6 with MCI issues, to see how the Mediterranean ketogenic diet and American Heart Association diet influences the patients' cognitive functions, specifically "Alzheimer’s markers in cerebrospinal fluid and gut bacteria".

While Dr. Yadav said more research needed to be done to determine more specifics, he said this study shows that there is a connection between the keto diet in reducing harmful fungi in the gut which has been associated with Alzheimer’s symptoms.

https://neurosciencenews.com/alzheimers-gut-fungi-keto-diet-16939/amp/

For further reading on the subject, see https://journals.sagepub.com/doi/10.1177/0300060520925930

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Microbiome Health Chart, October 2020 (click on chart to ZOOM IN)

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CLICK ON CHART TO ZOOM IN. CLICK ON CHART TO ZOOM IN. CLICK ON CHART TO ZOOM IN. CLICK ON CHART TO ZOOM IN. CLICK ON CHART TO ZOOM IN. CLICK ON CHART TO ZOOM IN. CLICK ON CHART TO ZOOM IN. CLICK ON CHART TO ZOOM IN.
This chart shows connections between our gut microbiome and various ailments or diseases, and offers food, herbal remedies, or supplements which may give relief to those ailments by positively impacting the microbiome.
This is not medical advice, so consult your doctor before making any health related decisions. Copyright (C) Herbsprout.com/ MobileZinger LLC.
#herbs #herbalmedicine #plantnutrition #health #spices #diet #gutmicrobiome #bacteria #healthinnovation #datascience #ai #artificialintelligence #machinelearning #mindbody #healthtech

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2 short chain fatty acids in the gut tied to breast cancer treatment efficacy

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October is Breast Cancer Awa... October is Breast Cancer Awareness Month; source: depositphotos.com
Just as we have reported last week about how the presence of butyrate supports a healthy gut, on the other hand, it can be detrimental to breast cancer chemotherapy. According to a September 17 2020 report in the American Journal of Managed Care (AJMC), 2 short chain fatty acids (SCFAs), propionate and butyrate, have been identified as tied to the efficacy of breast cancer chemotherapy (1). The study was conducted in Scotland led by Kirsty Ross, MBChB, MSc, a specialist registrar in medical oncology at the Beatson West of Scotland Cancer Centre, Glasgow, United Kingdom. The Beatson West Cancer Centre studied 21 patients with early-stage breast cancer.

The SCFAs were shown to be lower in the gut bacteria of patients achieving pathological complete response (pCR) compared with those not achieving pCR after surgery. According to Ross and her colleagues, they "dampen down the immune system’s ability to target cancer cells", as quoted in the AJMC article (1).

This points back to the fact that when it comes to personal health, it is very personal, and what is healthy for one person is not necessarily healthy for another person. As Herbsprout article quoted Viome CEO Naveen Jain, "one man's food is another man's poison." (2)

1. https://www.ajmc.com/view/gut-microbiota-may-influence-pcr-in-early-stage-breast-cancer

2. https://en.bloguru.com/healthtech/373232/one-mans-food-is-another-mans-poison
#gutmicrobiome #bacteria #healthinnovation #health #datascience #ai #healthtech #breastcancer #cancer #obesity #cardiovasculardisease

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Topically applying a probiotic to skin improves eczema

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Topically applying a probiotic t...
A September 09 2020 Medical Express article reported that experimental probiotic skin therapy using strains of live Roseomonas mucosa bacteria was isolated, grown, then applied to children with eczema. The application resulted in long term (up to 8 months) of relief from eczema symptoms. Roseomonas mucosa is a bacteria that naturally lives on the skin (1).

In the study of 20 children suffering from eczema, researchers found that topically applying Roseomonas mucosa bacteria to the skin showed a 50% improvement in 17 of the 20 recipients. The test results were also confirmed to reduce inflammation and symptoms of eczema and atopic dermatitis through tests of 10 adults, and 5 children (2).

1. https://medicalxpress.com/news/2020-09-probiotic-skin-therapy-eczema-children.amp

2. https://stm.sciencemag.org/lookup/doi/10.1126/scitranslmed.aaz8631

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The health benefits of butter

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The health benefits of butter
One common misconception is that butter is not healthy for you because it is fattening. It is true. It is fattening, but in a good way; it contains good fat. Butter is a good source of healthy fat, omega-3 fatty acids, particularly unsaturated, organic butter. It is the best, richest dietary source of a short chain fatty acid (SCFA) called butyrate.

The microbiome in our gut are known to metabolize acetate, propionate, and butyrate (at 60%, 25%, and 15% respectively), according to Dr. Deanna Minich (1). Butyrate is rich source of energy for the cells in our gut.

Butyrate is the energy source for cells that line the wall of our gut and helps prevent diarrhea and other digestive health issues. Beyond that, it plays a key role as an anti-inflammatory, gene regulation, and maintaining a balanced immune system.

In addition to butyrate, Butter is an excellent source of vitamin A, Vitamin E, and another fat called conjugated linoleic acid (CLA), which is also known to be an anti-inflammatory and provide immune support (2).

1. https://www.deannaminich.com/the-benefits-of-butter-a-rich-source-of-butyrate/

2. https://www.healthline.com/nutrition/is-butter-bad-for-you#cla
#gutmicrobiome #bacteria #healthinnovation #health #datascience #ai #healthtech #obesity #cardiovasculardisease

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