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New research combines artificial intelligence (AI), genetics, and multi-omics analyses to explore how metabolites produced by gut bacteria might influence Alzheimer’s disease (AD), according to a May 28 2024 Cell Report and PsyPost.

There is a noticeable change in the gut microbiome of AD patients. AD is marked by the accumulation of amyloid-beta plaques and tau protein tangles in the brain, which interfere with neural function and lead to cell death, according to the PsyPost report.

 

The study, conducted by Feixiong Cheng and his team from the Cleveland Clinic Genome Center, the Luo Ruvo Center for Brain Health, and the Center for Microbiome and Human Health, demonstrate a systems biology framework to uncover the GPCR (G-protein-coupled receptors) targets of human gut microbiota in AD and other complex diseases.

 

Gut metabolites are the key to many physiological processes in our bodies, and for every key there is a lock for human health and disease, says Cheng. Cheng and his team decided to map out the interactions between these metabolites and the human receptors they affect using Ai. They successfully predicted the interactions between over a million metabolite-receptor pairs, refining our understanding of the gut-brain axis.