Herbsprout.com

Chamomile from the Daisy family

10月

7日

Chamomile's daisy-like flowers contain volatile oils (including bisabolol, bisabolol oxides A and B, and matricin) and flavonoids (particularly a compound called apigenin) which are anti- allergenic and help with relief of cold symptoms and asthma. Chamomile is also anti-inflammatory and aids in alleviating colds and stomach ailments.

The common applications for chamomile include chamomile tea or essential oils, which aid in relaxation. It acts as a mild sedative and muscle relaxant.
Further information provided by Integrative Medicine and published by Science Direct is available at https://www.sciencedirect.com/topics/medicine-and-dentistry/chamomile.

Herbs that support "the happy chemical", microbiome health

10月

5日

Scientists have found that differences in a person’s gut can be a clue to our specific health propensities, to cancers, but also something as immediate as our daily mood, behaviors, even happiness. For example, 90% of the well-known serotonin neurotransmitter is made in the body’s digestive tract, according to a 2015 report by CalTech (“Microbes Help Produce Serotonin in Gut”, April 09, 2015). Serotonin is the chemical often referred to as the “happy chemical” and the balance of serotonin in our body influences our mood. A deficiency of serotonin can lead to depression.

Before getting into the research, what herbs support "healthy happy chemicals"? Herbs that help boost serotonin levels include oatstraw, which is loaded with B vitamins, and the roots of angelica, burdock, dandelion, ginseng, wild yam and black cohosh. There are lots of natural supplements containing these herbs and foods that you can buy online. You can also find supplements that contain L-tryptophan that supports serotonin synthesis, and vitamin B3 (magnesium glycenate) which helps metabolize fats, proteins, and carbohydrates. Basil contains serotonin boosting eugenol and rosmarinic acid.

As mentioned, there is growing evidence that the microbiome in our gut contribute not only to various body and brain diseases, but also to our mood and behavior relevant to many psychiatric and neurological disorders (Microbiome Journal, August 25, 2017). In particular, it has been repeatedly demonstrated that manipulation of the gut microbiome modulates anxiety-like behaviours, and our response to fear. The neural circuits that underlie anxiety- and fear-related behaviours are complex and heavily depend on functional communication between the amygdala and prefrontal cortex (PFC). Research at the University of California Los Angeles (UCLA) found a link between our stomach and a region of our brain that regulates mood and behavior, according IFLScience.com’s Robin Andrews (Source: “Our Gut Microbes Strongly Influence Our Emotional Behaviors,” IFL Science, July 4, 2017). The UCLA study was the first to link this connection within humans, based on the study of 40 healthy woman showing “brain-gut-microbial interactions in healthy humans”, according to the American Psychosomatic Society, affecting their mood and behaviors. Likewise, the Microbiome Journal reports that “transcriptional networks within the amygdala and PFC of Germ-Free mice are altered. MicroRNAs (miRNAs) act through translational repression to control gene translation and have been implicated in anxiety-like behaviours.” (See Microbiome Journal, August 25, 2017).

These results suggest that the microbiome is necessary for appropriate regulation of miRNA expression in brain regions implicated in anxiety-like behaviours.

"Serotonin is an important neurotransmitter and hormone that is involved in a variety of biological processes. The finding that gut microbes modulate serotonin levels raises the interesting prospect of using them to drive changes in biology," says Hsiao in the Caltech Journal. Hsao is quoted here from the CalTech journal Cell, April 09, 2015 issue.

#ai #artificialintelligence #bacteria #datascience #diet #gutmicrobiome #health #healthinnovation #healthtech #herbalmedicine #herbs #machinelearning #mindbody #neurotransmitters #plantnutrition #sertonin #spices #thehappychemical

A “Tsunami” of Ai is Coming to Health Care

10月

2日

1. Describe - handcrafted, rule based, symbolic knowledge.
2. Categorize - deep neural network, statistical learning.
3. Explain - contextual adaption, perceived learning and reasoning.

Serial entrepreneur and Viome CEO Naveen Jain believes there is a big wave of Ai coming to the health sector. “There is a tsunami that's coming," he told CNBC in a TV interview from the Slush technology conference in Helsinki, Finland (December 01, 2017). Jain partly attributes this tsunami to the huge demand for sensors that are driving down the prices, making Ai technology more available to the masses. "The sensors are becoming so cheap. For the first time in our lifetime, we can look deep inside our body (using sensors) to know exactly what is going on," he told CNBC. Jain believes food could become the "next drug," eliminating the need for traditional medicine.

On October 01, 2019, his company Viome was given a highly coveted endorsement in the form of research published about "A Robust Metatranscriptomic Technology for Population-Scale Studies of Diet, Gut Microbiome, and Human Health" in the International Journal of Genomics (Volume 2019, Article ID 171874 about Viome Inc., Los Alamos, NM 87544, USA). The report states that "Humans have co-evolved with the microbiome and have become dependent on its biochemical output, such as certain vitamins and short-chain fatty acids". (see full report, https://doi.org/10.1155/2019/1718741 ).

16S rRNA VS. METATRANSCRIPTOMIC SEQUENCING:

The report explains in detail the chasm of difference between the 16S r RNA and metatranscriptomic sequencing.

16S rRNA gene sequencing tracks a small portion of the prokaryotic 16S ribosomal RNA gen, but does not measure the biochemical functions of the microorganisms or distinguish living from dead organisms. It also excludes some bacteria, most archaea, and all eukaryotic organisms and viruses, resulting in a limited view of the gut microbiome ecosystem, according to the October 1 report.

Metatranscriptomic analysis (metatranscriptomics, RNA sequencing, and RNAseq) offers insights into what the gut microbiome are actually doing and why and how they are doing it. Viomega can make classifications based on a database of 110,000 microbial genomes, and quantitative microbial gene expression analysis using a database of 100 million microbial genes. "The biochemical activities of the gut microbiome by quantifying expression levels of active microbial genes, allowing for the assessment of pathway activities, while also providing strain-level taxonomic resolution for all metabolically active organisms and viruses," says the report. Viome's Viomega now makes this process affordable as well for the first time.

Naveen Jain founded Viome in 2016, a leading personalized microbiome gut sequencing technology company that uses deep machine learning and data science to offer optimal health care solutions for its customers. One of Jain’s “Moonshot” goals is to “truly make illness optional.” To do so, we must “think like the future has already arrived.”

Health care is one of those key global challenges facing this generation. The wholistic approach to wellness that has prevailed for centuries in Asia is being explored in a much broader scale with advanced Ai (artificial intelligence), data science, and other technology by the scientific communities in the U.S. and elsewhere that were not available to previous generations.

What Jain and his team at Viome are using Ai to discover a deeper and more detailed understanding of the mind and body. "Ai is going to play the biggest role because there is so much more data that no humans can ever process," he said.

#ai #artificialintelligence #bacteria #datascience #gutmicrobiome #healthinnovation #healthtech #machinelearning #mindbody

Ayurveda's "person-centric", non-standardized approach to health

10月

1日

Ayurvedic health is a 3,000 hear old holistic approach to an individual's personal health from India based on the three

Doshas: Vata (air, ether), Pitta (fire), and Kapha (water, earth).

How is Ayurvedic health different from the other approaches to health care? The modern scientific approach has been focused on standardization and applying solutions that work for the majority of people, such as if you get sick, you take this particular medicine and you will be healed of the ailment.

Ayurveda on the other hand, is person-centered vs. pathology-centered. It takes the approach that respects and considers the uniqueness of each individual in applying health care solutions. Ayurveda works with all levels of the person, the physical, mental, and spiritual, and both internal (microcosm) and external factors (macrocosm).

It believes each individual must take responsibility for their own health with a preventive, natural approach to addressing our symptoms and health issues.

#ai #artificialintelligence #ayurveda #bacteria #datascience #diet #doshas #gutmicrobiome #health #healthinnovation #healthtech #herbalmedicine #herbs #machinelearning #mindbody #plantnutrition #spices

Microbiome's connection to autism

9月

26日

Research is being administered about the influence of gut microbiomes on everything from autism, multiple sclerosis, PTSD, Parkinson’s Disease and brain health to cancer, depression, obesity, diabetes and weight loss. It has become widespread as major research institutions and universities are conducting studies on the subject.

An article in The Guardian, “Gut bacteria regulate nerve fibre insulation” (Mo Costandi, April 05, 2016) claims that “alterations in our gut bacteria composition may be connected to a wide range of neurological and psychiatric conditions, including autism, chronic pain, depression, and Parkinson’s Disease.” Psychosomatic Medicine reported that “various factors play a role (in PTSD), including a lack of social support and low levels of the neurotransmitter neuropeptide Y (see British Psychological Society blog, November 22, 2017).

Research on mice in early 2019 done by MIT and the University of Massachusetts Medical School found similar impacts of identifiable microbial strains. Researchers found that the gut microbiome composition of the mother’s gut can influence whether maternal infection leads to autistic-like behaviors in offspring. They also discovered the specific brain changes that produce these behaviors. The same MIT report also referenced a 2010 study where all children born in Denmark between 1980 and 2005 found that severe viral infections during the first trimester of their mother’s pregnancy led to risk for autism by three times.

In a 2016 Science paper, Drs. Gloria Choi and her husband Jun Huh found that types of immune cells known as Th17 cells, and their effector molecule, called IL-17, are responsible for this effect in mice. IL-17 then interacts with receptors found on brain cells in the developing fetus, leading to irregularities that the researchers call “patches” in certain parts of the cortex known as the somatosensory cortex. When the researchers restored normal levels of brain activity in this area of the brain, they were able to reverse the behavioral abnormalities. They were also able to induce the behaviors in otherwise normal mice by over stimulating neurons in the somatosensory cortex.

#Braindiseases #autism #effectormolecules #microbiomes #molecules #neurotransmitters

Will gut bacteria replace drugs as medicine?

9月

23日

In a paper published Wednesday, August 28, 2019 in the journal Nature, scientists found that certain bacteria molecules can interact with protein receptors in mice, receptors which humans also have. The specific receptors found by microbiologist Sean Brady and his team at Rockefeller University, made the connection that certain gut bacteria are making molecules that improve glucose regulation in mice, a key step toward harnessing molecules to treat illness.

In Brady's study, signaling molecule in the bacteria known as N-acyl amides are involved in signaling pathways, helping the body regulate itself. Knowing this could enable us to use microbes to not only address symptoms as so much of modern medicine does, but apply healthy microbes to treat the source of an illness.

See Popular Science article, https://www.popsci.com/gut-bacteria-medicine/?zLzbIvdKfbdGTwyp.03).

Can you get drunk without drinking alcohol? Yes.

9月

21日

Too much junk food?

The answer is yes, and it's more common than you think. Researchers have discovered a new culprit to liver damage without even picking up your favorite alcoholic drink. That culprit is the bacteria in your gut, specifically a strain called Klebsiella pneumonia.

Not everyone's k. pneumonia creates liver damaging levels of alcohol. This gut bacteria produces a large amount of alcohol in the body in a select number of people. These bacteria reside in over 60% of patients who contract non-alcoholic fatty liver disease (NAFLD), in some leading to fibrosis and in fewer, the life threatening cirrhosis of the liver. An estimated 25% of the human population has alcohol producing bacteria in their body.

So "what's the point?" quoting the local AA meeting reading. "The point is" . . . well, watch what you eat. Apparently, non-alcohol induced inebriation is triggered by eating too much carbo- rich, sugary foods, according to a study by co-author Jing Yuan, a professor and director of the bacteriology laboratory at the Capital Institute of Pediatrics in Beijing. He recently shared his team's findings with Live Science (see article,
https://www.livescience.com/alcohol-producing-gut-bacteria-harm-liver.html ).

The good news is that even if you're an "alcoholic" without consuming even a drop of alcohol, the new finding offers opportunity to diagnose and treat NAFLD early. . . And a solution- "put down that sprinkle donut!"

#alcohol #drinking #gutbacteria #guthealth #liverdamage #liverdisease #microbiome

"Miracle bugs" - Microbial Influences on MS

9月

20日

Research suggests that microbiomes influence brain health in a variety of ways.

Innovative entrepreneurs and researchers are able to isolate, using Ai, specific strains of bacteria that directly affect the neuro-degeneration of MS (multiple sclerosis) patients, as one of many examples.

Miracle “bugs”

Getting down to specifics, one study identified a connection between bacterial strains Akkermansia muciniphila and Acinetobacter calcoaceticus, and multiple sclerosis. A study conducted by the University of California San Francisco (UCSF) found a connection between gut microbiomes and neuron-degeneration characterized by MS (September 11, 2017 Online Edition of Proceedings of the National Academy of Sciences (PNAS). In the study, postdoctoral UCSF researcher Egle Cekanaviciute, PhD, and collaborators found specific species of bacteria in the gut among 71 MS patients they analyzed that were not present in 71 healthy control subjects. The study found that Akkermansia muciniphila and Acinetobacter calcoaceticus—triggered human immune cells to become pro-inflammatory, while another found at lower than usual levels in MS patients — Parabacteroides distasonis—triggered immune-regulatory responses. Sergio Baranzini, PhD, a professor of neurology at UCSF explains in the article that “twins only share an MS diagnosis about 35 percent of the time.” Baranzini and Cekanaviciute’s studies took the research a step further, to identify the effects of specific microbiomes – the increased presence of ones that cause harmful effects versus the decreased presence of ones that are helpful – how they actually impact human health.

This demonstrates concrete evidence associating the role of microbiomes and MS. Baranzini and Cekanaviciute’s research took the research a step to the next level. It identified the effects of specific microbiomes - the increased presence of ones that cause harmful effects versus the decreased presence of ones that are helpful - how they actually impact human health. With this knowledge, scientists have the tools now to potentially cure degenerative diseases like MS for the first time!

The brain – microbial body connections seem endless, as the engine of microbial research redefines the health care industry.

#ai #artificialintelligence #bacteria #datascience #gutmicrobiome #healthinnovation #healthtech #machinelearning #mindbody

Chinese herbal impacts on gut health

9月

18日

Radix Scutellariae also known as baical skullcap seed/ root is the root of Scutellaria baicalensis, the source of the 2,000 year old Chinese medicine Huang Qin.

In addition to animal studies, several studies of natural products have been performed on human gut microbiota. Gegen Qinlian Decoction (GQD), a traditional Chinese herbal formula, reshaped the gut microbiota in a clinical study by China Pharmaceutical University (see reference below) in which 187 T2D (type 2 diabetes) patients participated. The data showed that the symptoms of T2D, such as fasting blood glucose levels and hemoglobin A1c (HbA1c) levels, were ameliorated in GQD-treated patients, with increased amounts of beneficial bacteria, including Faecalibacterium, Gemmiger, Bifidobacterium, and Escherichia. Radix Scutellariae (baical skullcap seed/ root) in GQT is the main herbal component that facilitated the potent inhibition of MMP-2. MMP-2 (matrix metalloproteinase-2) contributes to cancer cells migration and the progression of breast cancer, among others. GQT is also widely used to treat diarrhea and inflammation symptoms in various gastrointestinal disorders. (see https://www.sciencedirect.com/science/article/pii/S0753332218369075).

Another clinical study involving ten obese Korean women was conducted to investigate the antiobesity activity of the water extract of Ephedra sinica Stapf. This study revealed that, in seven of the ten obese women, BW and body mass index (BMI) were decreased after administration of this herb. (source: State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, Department of Basic Medicine, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, China. Contact Qinglong Guo; qinglongguo@hotmail.com and Na Lu; nalu@cpu.edu.cn). ).

#ai #artificialintelligence #bacteria #datascience #diet #gutmicrobiome #health #healthinnovation #healthtech #herbalmedicine #herbs #machinelearning #mindbody #plantnutrition #spices

Parkinson's may originate in the gut

9月

15日

Researchers found evidence that Parkinson's disease is formed from α-synuclein (alpha-synuclein) proteins and their dysfunction begins in the intestine. Parkinson's disease happens when these proteins build up and solidify, which damages nerve cells.

Parkinson's symptoms include shakiness in the hands and limbs, difficulty walking, dizziness, rigidity, dementia, difficulty thinking, among others. Parkinson's disease patients often already show progressed nervous system damage at the time of diagnosis.

The good news is the damaged a-synuclein proteins originate in the small intestines and migrate slowly up to the brain. It is now possible to detect pathological a-synuclein in the gut up to twenty years before diagnosis, according to Per Borghammer who led the study, a professor at the Department of Clinical Medicine at Aarhus University, Denmark. If detected early in the gut, treatment can begin even before symptoms begin to show in the Parkinson's patient.

The research was originally reported September 13, 2019 by the American Association for the Advancement of Science news release on its Eureka Alert!

See https://www.eurekalert.org/pub_releases/2019-09/au-pdm090219.php

Herbsprout.com

フリースペース

Chamomile from the Daisy family

Herbs that support "the happy chemical", microbiome health

A “Tsunami” of Ai is Coming to Health Care

Ayurveda's "person-centric", non-standardized approach to health

Microbiome's connection to autism

Will gut bacteria replace drugs as medicine?

Can you get drunk without drinking alcohol? Yes.

"Miracle bugs" - Microbial Influences on MS

Chinese herbal impacts on gut health

Parkinson's may originate in the gut

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