Gut bacterial chemical promotes obesity

2月

11日

Delta-valerobetaine, a bacterial metabolite is said to provide a starting point to understand our gut microbiome as a link between diet and body composition, according to Dean Jones, professor of medicine at Emory University School of Medicine and co-senior author of the paper in a January 31, 2022 Futurity.org article. Delta-valerobetaine was identified by comparing the livers of conventionally housed mice with those in germ-free mice.

Researchers found that the delta-valerobetaine decreases the liver’s ability to burn fat during fasting periods. The molecule was first identified by Ken Liu, a former molecular and systems pharmacology graduate student who is the first author of the paper.

Certain varieties of bacteria are believed to produce more delta-valerobetaine than others. The Futurity.org article says the Cleveland Clinic confirmed that TMAO (trimethylamine N-oxide) of which Delta-valerobetaine is a precursor, is associated with cardiovascular disease.

https://www.futurity.org/metabolite-intestinal-bacteria-obesity-2689822/

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Gut bacterial chemical promotes obesity