GUT microbiome byproduct found to cause heart disease

4月

16日

A March 05, 2020 study published in Cell, found that a gut microbiome byproduct phenylacetylglutamine (PAG) is linked to development of "cardiovascular disease, including heart attack, stroke and death." Research in this field is critical as diabetes and cardiovascular disease (CVD) have become the leading cause of death and disease worldwide.

Phenylalanine is an amino acid found in many foods, including plant- and animal-based protein sources like meat, beans and soy. The researchers found that when phenylalanine is broken down by microbes in the gut, it produces a byproduct (metabolite) that ultimately shows up in blood called phenylacetylglutamine (PAG) that contributes to heart disease (led by Stanley Hazen, M.D., Ph.D., chair of the Department of Cardiovascular & Metabolic Sciences in Lerner Research Institute and co-section head of Preventive Cardiology & Rehabilitation in the Miller Family Heart, Vascular & Thoracic Institute).

(see source: https://www.cell.com/trends/endocrinology-metabolism/fulltext/S1043-2760(20)30024-2)

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GUT microbiome byproduct found to cause heart disease