Neuroscience News reported on June 19 2025 that researchers analyzed 12 studies the microbiomes of treated, untreated, and healthy individuals.
The analysis found bipolar patients who responded well to treatment tended to have gut profiles more similar to healthy individuals. The gut-brain axis appears to influence both medication effects and mood regulation.
These findings suggest a possible role of the gut-brain axis in determining the success of bipolar therapies and point to future possibilities for microbiome-informed personalized medicine, adds the report.