Nacalai USA's Blog

Please click link below to view application data using DL-Amino Acid Labeling Kit.
https://www.nacalai.co.jp/cosmosil/data/csmosrchlst.cfm?UpdDate=20210930000000&NameKey=&NameSrch=2&CASNo=&MultiClassify=01&RyuKei=0&AppNo=&kensu=20&lc=E

ex. D-DLDA-DL-Amino Acids
https://www.nacalai.co.jp/cosmosil/data/png/AP/AP-1844.png

--- Application of Lorazepam and Its Impurities A-E ---
Data courtesy of Genichiro, Tsuji, Ph. D.,
Division of Organic Chemistry, National Institute of Health Sciences
https://www.nacalai.co.jp/cosmosil/data/csmosrchpng.cfm?sFile=AP-1847&columnID=011&lc=E&pg=Application



Click the link below to get more information on COSMOSIL PBr.
>> https://www.nacalaiusa.com/products/view/238/cosmosil-pbr

Application of Sesamin metabolites
https://www.nacalai.co.jp/cosmosil/data/csmosrchpng.cfm?sFile=AP-1846&columnID=008&lc=E&pg=Application

Data courtesy of Takuto Kumano, Ph. D. and Michihiko Kobayashi, Ph. D.,
Graduate School of Life and Environmental Sciences, The University of Tsukuba


Click the link below to get more information on COSMOSIL π-NAP.
>> https://www.nacalaiusa.com/products/view/107/cosmosil-pi-nap

- COSMOSIL RNA-SEC HPLC Column -
Presented here are two HPLC methods, a size exclusion-based method for the purification of long mRNA, and a reverse-phase method for the purification of oligonucleotides.

Please click the link below to find more information:
https://lnkd.in/gCA_JD9S

COSMOSIL / COSMOCORE PBr Column
* Separation of hydrophilic compounds in reversed-phase conditions *

- Separate hydrophilic compounds in reversed-phase conditions
- Alternative selectivity to C18 column
- Simple mobile phase condition compared to HILIC

Click the link below to get more information.
>> https://www.nacalaiusa.com/products/view/280/cosmocore-2-6pbr

7,800 COSMOSIL applications are now usable by clicking the link below which is in Nacalai Tesque, Inc. The application is searchable by sample category, sample name, CAS No., column name and particle size.

COSMOSIL Application:
https://www.nacalai.co.jp/cosmosil/data/csmosrchtop.cfm?lc=E

COSMSOIL Column Selection Guide:
https://www.nacalaiusa.com/products/view/425/column-selection-guide

Taurine is a biologically significant molecule with a zwitterionic character, which makes it a difficult analysis target. COSMOSIL HILIC has a unique anion-exchange mechanism which allows strong retention of taurine with good peak shape. It is USP packing type L104, specified on the official monogram for taurine.

>> General information on COSMOSIL HILIC
https://www.nacalaiusa.com/products/view/96/cosmosil-hilic

>> USP revision notice for taurine (PDF file)
https://www.uspnf.com/sites/default/files/usp_pdf/EN/USPNF/revisions/taurine-rb-notice-20190301.pdf

COSMOSIL Application, which includes more than 7,700 applications using COSMOSIL/COSMOCORE columns, is now usable by clicking the link below which is in Nacalai Tesque, Inc. The application is searchable by sample category, sample name, CAS No., column name and particle size.

COSMOSIL Application
https://www.nacalai.co.jp/cosmosil/data/csmosrchtop.cfm?lc=E

Comparison of Retention Behavior between Supercritical Fluid Chromatography and Normal-Phase High-Performance Liquid Chromatography with Various Stationary Phases

Reference:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6650800/

COSMOSIL SFC Columns:
https://www.nacalaiusa.com/products/list/63/cosmosil-sfc-column

Due to the lack of retention on ODS columns, oligosaccharides have typically been analyzed on specialty sugar columns. We have successfully analyzed inulins using COSMOSIL Sugar-D, a specialty column for saccharide analysis, and PBr, a unique reversed-phase column for polar and non-polar analytes.

About Inulin
Inulin structure Inulin (G-Fn-F) is a polysaccharide composed of a glucose unit (G) bonded to multiple fructose units (F). It is an indigestible, water-soluble dietary fiber, abundant in the roots of chicory and tubers of Jerusalem artichokes. Recently, oolong tea with inulin has been released as a functional food in Japan on the basis that inulins feed intestinal bacteria by forming short-chain fatty acids and facilitate the peristaltic movement in the bowels. In the literature as well, there are references to inulin's effect on bowel movements.

Click the link below for more information;
https://www.nacalai.co.jp/global/cosmosil/inulin_analysis.html