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Medixo Centre is a leading international specialty online pharmacy that provides specialty medication to people all over the world with specialized needs such as Cancer, HIV/AIDS, Arthritis, Diabetes, Hepatitis, Multiple Sclerosis, Anti-fungal, Kidney Diseases, Osteoporosis and more. We supply generic drugs as well as brand name medicines. along with 100% refund policy.

How much does (Sorafenat) sorafenib cost?

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Anti Cancer Anti Cancer
Sorafenat 200 mg tablets – Quick Thoughts

Sorafenat (Sorafenib) is an anticancer drug used in medical practice for treating malignant tumors in the kidneys, liver, and thyroid gland. The drug is used to suppress metastasis and the spread of metastases from these organs throughout the body. The drug is a conservative treatment of tumors.

Release form composition and packaging
The drug is made in the form of tablets that contain 200 mg of sorafenib tosylate.

As auxiliary substances are used:

microcrystalline cellulose:
magnesium stearate;
croscarmellose sodium and lauryl sulfate;
hypromellose.
The outer film shell consists of macrogol, a red dye of iron oxide, titanium dioxide, and hypromellose. Tablets have a biconvex round shape and a red tinge. Each blister pack contains 28 units. the drug, in a cardboard bundle – 4 blisters.

Pharmachologic effect
Sorafenib price – an anticancer drug. The mechanism of action is based on multi-kinase inhibition – the drug suppresses mitotic division and further infiltration of tumor cells into the tissue.

When oral doses are prescribed, the active substance sorafenibosylate reduces the functional activity of intracellular kinases and phosphotransferases located on the cell surface. The latter include:

KIT;
VEGFR-2;
RET;
PDGFR-B;
VEGFR-1;
FLT-3;
VEGFR-3.
Kinases within tumor units are referred to as: c-CRAF, standard and mutant BRAF. Theoretically, membrane and intracellular phosphotransferase are involved in apoptosis, signaling activity and the formation of new blood vessels (angiogenesis).

After oral administration, the bioavailability of sorafenib varies from 38 to 50%, depending on the individual characteristics. The film membrane is destroyed by intestinal esterases.

When absorbed by the microvilli of the small intestine, tosylate sorafenib enters the systemic vascular bed, where it reaches maximum plasma values ​​within 3 hours. Food intake does not affect the speed and completeness of absorption of the drug, but when consumed with fatty foods, bioavailability decreases by 30%.

The active substance is associated with albumin and other proteins in the blood by 99.5%. With the help of such a complex, the drug penetrates into the malignant cells. Tosylate sorafenib is transformed in the liver cells due to oxidative reactions and gluconization. The resulting metabolic products break up in the digestive tract under the action of glucuronidase bacterial flora.

Indications for use Sorafenib
The drug is used to suppress malignant growth in the following cases:

metastatic cancer of the kidney cells;
metastatic differentiated tumor of the thyroid gland, which is resistant to radioactive iodine isotopes (this type of malignant neoplasm can infiltrate into local tissues);
liver cancer.
Dosage and administration of Sorafenib
Per day is recommended to take 4 times 0.2 g (800 mg) of the drug. The dosage is divided into 2 doses for use into the intervals between eating food or with food containing a low or medium level of fat. Tablets need to be swallowed without chewing (mechanical grinding reduces absorption and bioavailability), drinking plenty of liquid.

Mode of application
The recommended daily dose of sorafenib is 800 mg in 2 doses, either between meals or with a diet containing low or moderate amounts of fat.

Treatment is continued for as long as clinical efficacy persists or until an unacceptable toxic effect appears.

The development of adverse reactions may require the temporary cessation and / or reduction of the dose of sorafenib. If necessary, the dose of sorafenib can be reduced to 400 mg 1 time / day.

With the development of skin toxicity, a dose reduction of sorafenib is required.

Source: http://sorafenatprice.edublogs.org/2019/06/04/how-much-does-sorafenat-sorafenib-cost/
#sorafenat #sorfenatprice #buysorfenaibonline

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Velpanat tablets: Buy Epclusa online price in India & China

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Velpanat tablets: Buy Epclusa ...
What is Velpanat Epclusa?

Velpanat (Epclusa) contains a combination of Sofosbuvir and Velpatasvir. are antiviral drugs that prevent the reproduction of the hepatitis C virus (HCV) in your body. Epclusa is used to treat chronic hepatitis C in adults with the genotype HCV 1, 2, 3, 4, 5, or 6. Epclusa is given in combination with another antiviral drug called ribavirin in people who also develop cirrhosis.

Important information

Epclusa is sometimes used in combination with ribavirin. Ribavirin can cause birth defects or death in an unborn baby. Do not use ribavirin if you are pregnant, or if you are a man, and your sexual partner is pregnant. Use effective birth control to prevent pregnancy while using Epclusa and ribavirin and for at least 6 months after the end of treatment.

Slideshow Top 10 Most Expensive Diseases Read the treatment guide or patient instructions that are provided with each medicine in your combination therapy. Do not change the dose or timing of medication without consulting a doctor.

If you have ever had hepatitis B, Epclusa may cause this condition to return or worsen. You will need frequent blood tests to check your liver function.

Where can I get more information?

Your pharmacist can provide more information about Epclusa Price
#velpanat

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