Herbsprout.com

2 short chain fatty acids in the gut tied to breast cancer treatment efficacy

9月

26日

October is Breast Cancer Awareness Month; source: depositphotos.com

Just as we have reported last week about how the presence of butyrate supports a healthy gut, on the other hand, it can be detrimental to breast cancer chemotherapy. According to a September 17 2020 report in the American Journal of Managed Care (AJMC), 2 short chain fatty acids (SCFAs), propionate and butyrate, have been identified as tied to the efficacy of breast cancer chemotherapy (1). The study was conducted in Scotland led by Kirsty Ross, MBChB, MSc, a specialist registrar in medical oncology at the Beatson West of Scotland Cancer Centre, Glasgow, United Kingdom. The Beatson West Cancer Centre studied 21 patients with early-stage breast cancer.

The SCFAs were shown to be lower in the gut bacteria of patients achieving pathological complete response (pCR) compared with those not achieving pCR after surgery. According to Ross and her colleagues, they "dampen down the immune system’s ability to target cancer cells", as quoted in the AJMC article (1).

This points back to the fact that when it comes to personal health, it is very personal, and what is healthy for one person is not necessarily healthy for another person. As Herbsprout article quoted Viome CEO Naveen Jain, "one man's food is another man's poison." (2)

1. https://www.ajmc.com/view/gut-microbiota-may-influence-pcr-in-early-stage-breast-cancer

2. https://en.bloguru.com/healthtech/373232/one-mans-food-is-another-mans-poison

#ai #bacteria #breastcancer #cancer #cardiovasculardisease #datascience #gutmicrobiome #health #healthinnovation #healthtech #obesity

Topically applying a probiotic to skin improves eczema

9月

24日

A September 09 2020 Medical Express article reported that experimental probiotic skin therapy using strains of live Roseomonas mucosa bacteria was isolated, grown, then applied to children with eczema. The application resulted in long term (up to 8 months) of relief from eczema symptoms. Roseomonas mucosa is a bacteria that naturally lives on the skin (1).

In the study of 20 children suffering from eczema, researchers found that topically applying Roseomonas mucosa bacteria to the skin showed a 50% improvement in 17 of the 20 recipients. The test results were also confirmed to reduce inflammation and symptoms of eczema and atopic dermatitis through tests of 10 adults, and 5 children (2).

1. https://medicalxpress.com/news/2020-09-probiotic-skin-therapy-eczema-children.amp

2. https://stm.sciencemag.org/lookup/doi/10.1126/scitranslmed.aaz8631

The health benefits of butter

9月

19日

One common misconception is that butter is not healthy for you because it is fattening. It is true. It is fattening, but in a good way; it contains good fat. Butter is a good source of healthy fat, omega-3 fatty acids, particularly unsaturated, organic butter. It is the best, richest dietary source of a short chain fatty acid (SCFA) called butyrate.

The microbiome in our gut are known to metabolize acetate, propionate, and butyrate (at 60%, 25%, and 15% respectively), according to Dr. Deanna Minich (1). Butyrate is rich source of energy for the cells in our gut.

Butyrate is the energy source for cells that line the wall of our gut and helps prevent diarrhea and other digestive health issues. Beyond that, it plays a key role as an anti-inflammatory, gene regulation, and maintaining a balanced immune system.

In addition to butyrate, Butter is an excellent source of vitamin A, Vitamin E, and another fat called conjugated linoleic acid (CLA), which is also known to be an anti-inflammatory and provide immune support (2).

1. https://www.deannaminich.com/the-benefits-of-butter-a-rich-source-of-butyrate/

2. https://www.healthline.com/nutrition/is-butter-bad-for-you#cla

#ai #bacteria #cardiovasculardisease #datascience #gutmicrobiome #health #healthinnovation #healthtech #obesity

Covid 19 virus lingers in the gut after recovering

9月

17日

A September 07 2020 article in Bloomberg said the coronavirus may remain in the gut for some time after clearing the respiratory system, according to Chinese University of Hong Kong researchers. They claim the coronavirus may continue to infect and replicate in the digestive tract.

Primarily spread through droplets in the air, a February 2020 study of 73 hospitalized coronavirus patients in Guangdong province, China found more than half tested positive for the virus in their stool. Fecal presence of coronavirus was found present in patients six days after testing negative of the virus.

This leads to the possibility that understanding the the presence of certain strains of bacteria in coronavirus patients could aid in the development of a microbiome- based remedy for treating the Coronavirus. They particularly showed a loss of protective microbes and a proliferation of disease-causing ones.

The Chinese University is offering free screening stool tests to travelers arriving at the airport since late March, and identified six infected children among more than 2,000 samples tested, accordingto the Bloomberg report.

https://www.bloomberg.com/amp/news/articles/2020-09-07/covid-19-patients-may-have-prolonged-gut-infection-study-finds

New discovery about how bacteria adheres to our gut's cell walls

9月

13日

Researchers at the University of Basel and ETH Zurich have found a new mechanism by which bacteria adhere to cellulose fibers on the cell walls of the human gut, according to an August 28 2020 article in Phys.Org.

The significance of understanding this is it helps us understand an important part of how our gut microbiome influences our health. Professor Michael Nash from the University of Basel and ETH Zurich studied combinations of "single-molecule atomic force microscopy, single-molecule fluorescence and molecular dynamics simulations", according to the report.

Researchers believe there is a dual binding mode, one significantly stronger than the other. The bacteria is believed to control the binding mode preference by modifying the proteins and the adherence strength. "This would allow switching from a low to high adhesion state depending on the environment," according to Nash. Learning this process and how it works may help scientists employ bacteria that adhere to certain disease targets, at the higher adhesion rate.

https://phys.org/news/2020-08-bacteria-adhere-fiber-gut.amp

#ai #bacteria #datascience #gutmicrobiome #health #healthinnovation #healthtech #longevity #microbiome #nutrition #wellness

Gut microbiome influences sleep patterns

9月

10日

Reseachers at University of Illinois at Chicago, conducted a rat study linking "disturbed sleep patterns, elevated blood pressure, and disruptions to the gut microbiome", according to a September 03 2020 New Atlas article. When studying the sleep patterns of rats, researchers found that abnormal sleep patterns developed increase in blood pressure. While this has been confirmed in previous human studies, new information about the gut microbiome was revealed in this study.

The study led by researcher Katherine Maki discovered an increase in the gut bacteria associated with inflammation. Theoretically,
Reseachers at University of Illinois at Chicago, conducted a rat study linking "disturbed sleep patterns, elevated blood pressure, and disruptions to the gut microbiome", according to a September 03 2020 New Atlas article. When studying the sleep patterns of rats, researchers found that abnormal sleep patterns developed increase in blood pressure. While this has been confirmed in previous human studies, new information about the gut microbiome was revealed in this study.

The study led by researcher Katherine Maki discovered an increase in the gut bacteria associated with inflammation. Theoretically, this suggests that probiotics could be a useful remedy in the future to address high blood pressure and hypertension.

https://newatlas.com/science/poor-sleep-high-blood-pressure-bacteria-gut-microbiome-hypertension/

Gut Bacteria’s role in cholesterol

9月

6日

According to an August 12 2020 article in Cell.com, the ismA genes in certain microbial strains can help reduce cholesterol levels in mice (1).

A study published in the journal of the Society of Applied Microbiology found that Lactobacillus plantarum TAR4 reduced cholesterol levels by as much as 48%. Lactic acid bacteria strains were isolated and examined for "acid tolerance, bile salt resistance and hypocholesterolemic properties," according to the mice study (2).

Sarahs-world.blog, the Asian dish Tapai, which is fermented cassava or rice, contains a special Lactobacilli strain that has probiotic effects in rats and can break down cholesterol as well (3).

The article states bacterium under investigation uses a network of "scaffold proteins and enzymes on the outer cell wall, referred to as a cellulosome network, to attach to and degrade cellulose fibers. These cellulosome networks are held together by families of interacting proteins."

It demonstrates that probiotic Lactobacillus plantarum TAR4 supplements can reduce bile acids and reduce cholesterol levels.

1. https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(20)30295-X?_returnURL

2. https://sfamjournals.onlinelibrary.wiley.com/doi/full/10.1111/jam.14678

3. https://sarahs-world.blog/bacteria-reduce-cholesterol/

自己紹介

By HerbSprout.com

https://herbsprout.home.blog/ HERBSPROUT ADVISORY BOARD: ___________________________

●Jenny Pandol, Co-owner/founder/ COO, Microbiome Learning Center;
●Dr. Sabine Hazan, Founder and CEO, Progenabiome and Ventura Clinical Trials;
●Naveen Jain, Founder & CEO, Viome
●Hans Parge, ex-Pfizer director;
●Rob Greenlee, VP, Libsyn;
___________________________

●Cindy Postma, essential oils;
●Chris Kenji Beer, herbs & microbiome;
●Ely Diana, translation/ support services.
___________________________

Cindy Postma has been a writer and editor across all disciplines. She has been an instructor of Asian studies at Kings College (Cambridge), Columbia, and Cornell. She received her PhD from Kyoto University, Masters from Columbia University, and undergraduate from The University of Washington. She is proficient in four Asian languages and French. ____________________________

I am Chris Kenji Beer, Herbsprout writer and editor. I come from a family of health nuts. My mom was a psyche major and shared her Japanese culinary tradition. Uncle Tetsuo was and cousin Satoru Harada is a surgeon. Aunt Shigeko was a dietitian in Hiroshima before complications from the nuclear fallout took her life. I am currently enrolled at Bastyr University's Ayurvedic Health Advisor program. In the past, I spent many years researching health care. I was published on the topic "Japanese Health Care for the Elderly" by the U.S. - Japan Foundation, and as co-author of health care reports for National Conference of State Legislatures Health Services Program, NW Asian Weekly, & as Editor/ co-Publisher of Asia Pacific Economic Review. Email us with questions or comments @ sales@mzinger.com. ____________________________

The contents of this webblog is not intended to be used to treat, cure, mitigate, or diagnose any medical condition. The readers must consult your doctor before you make any changes that could affect your health.

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